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    GR glutathione reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824631, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GR
    Official Full Name
    glutathione reductase
    Primary source
    TAIR:AT3G54660
    Locus tag
    AT3G54660
    See related
    Araport:AT3G54660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGR2; EMB2360; glutathione reductase
    Summary
    Encodes glutathione reductase that is most likely localized in the chloroplast.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (20229637..20233211, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tryptophan synthase alpha chain Neighboring gene RNI-like superfamily protein Neighboring gene Structural maintenance of chromosomes (SMC) family protein Neighboring gene proteophosphoglycan-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems. Marty L, et al. New Phytol, 2019 Dec. PMID 31372999
    2. Glutathione reductase 2 maintains the function of photosystem II in Arabidopsis under excess light. Ding S, et al. Biochim Biophys Acta, 2016 Jun. PMID 26906429
    3. Decreased glutathione reductase2 leads to early leaf senescence in Arabidopsis. Ding S, et al. J Integr Plant Biol, 2016 Jan. PMID 26031939, Free PMC Article
    4. Plastid-localized glutathione reductase2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance. Yu X, et al. Plant Cell, 2013 Nov. PMID 24249834, Free PMC Article
    5. Evidence of a significant role of glutathione reductase in the sulfur assimilation pathway. Cohen A, et al. Plant J, 2020 Apr. PMID 31782847

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evidence of a significant role of glutathione reductase in the sulfur assimilation pathway.
      Title: Evidence of a significant role of glutathione reductase in the sulfur assimilation pathway.
    2. Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems.
      Title: Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems.
    3. GR2 plays an important role in leaf senescence by modulating hydrogen peroxide and glutathione signaling in Arabidopsis.
      Title: Decreased glutathione reductase2 leads to early leaf senescence in Arabidopsis.
    4. Data indicate that glutathione reductase 2 (GR2) protects photosystem II (PSII) from excess light and maintains the function of acceptor side of PSII.
      Title: Glutathione reductase 2 maintains the function of photosystem II in Arabidopsis under excess light.
    5. Plastid-localized glutathione reductase-2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance.
      Title: Plastid-localized glutathione reductase2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115323.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding HDA PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione reductase
    NP_191026.1
    • glutathione reductase (GR); FUNCTIONS IN: glutathione-disulfide reductase activity, copper ion binding, ATP binding; INVOLVED IN: glutathione metabolic process; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Glutathione-disulphide reductase (InterPro:IPR006324), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099); BEST Arabidopsis thaliana protein match is: glutathione-disulfide reductase (TAIR:AT3G24170.3); Has 33740 Blast hits to 33692 proteins in 3140 species: Archae - 759; Bacteria - 24408; Metazoa - 813; Fungi - 438; Plants - 579; Viruses - 0; Other Eukaryotes - 6743 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20229637..20233211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115323.4 → NP_191026.1  glutathione reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42770
      UniProtKB/TrEMBL
      A0A178V6S0, A0A654FIH5, Q5FV38, Q940F6
      Conserved Domains (1) summary
      PLN02546
      Location:1 → 565
      PLN02546; glutathione reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42770.1

    Gene LinkOut

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