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    ACS acetyl-CoA synthetase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833655, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACS
    Official Full Name
    acetyl-CoA synthetase
    Primary source
    TAIR:AT5G36880
    Locus tag
    AT5G36880
    See related
    Araport:AT5G36880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetyl-CoA synthetase
    Summary
    Encodes a plastidic acetyl-coA synthetase. This enzyme plays a role in converting acetate to acetyl-coA in the plastids. It does not appear to be a major contributor to fatty acid biosynthesis based on mutant phenotypes. The enzyme seems to act as a monomer and may play an important role in preventing the toxic accumulation of fermentation products including acetaldehyde, acetate, and ethanol. It participates in the pyruvate dehydrogenase bypass pathway
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    Genomic context

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    See ACS in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    21
    Sequence:
    Chromosome: 5; NC_003076.8 (14534585..14540441, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glucan synthase-like 9 Neighboring gene beta glucosidase 42 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of acetyl-coenzyme a synthetase in Arabidopsis. Lin M, et al. Plant Physiol, 2008 Aug. PMID 18552233, Free PMC Article
    2. Failure to Maintain Acetate Homeostasis by Acetate-Activating Enzymes Impacts Plant Development. Fu X, et al. Plant Physiol, 2020 Mar. PMID 31874860, Free PMC Article
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036897.3
    NM_001344154.1
    NM_001344155.1
    NM_001344156.1
    NM_001344157.1
    NM_123046.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables acetate-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within acetate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acetyl-CoA biosynthetic process from acetate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetyl-CoA synthetase
    NP_001031974.2
    • acetyl-CoA synthetase (ACS); FUNCTIONS IN: acetate-CoA ligase activity; INVOLVED IN: metabolic process, acetate metabolic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acetate--CoA ligase (InterPro:IPR011904), AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: acyl-activating enzyme 17 (TAIR:AT5G23050.1); Has 68981 Blast hits to 63577 proteins in 3326 species: Archae - 1100; Bacteria - 43606; Metazoa - 2469; Fungi - 2489; Plants - 1499; Viruses - 1; Other Eukaryotes - 17817 (source: NCBI BLink).
    NP_198504.1
    • acetyl-CoA synthetase (ACS); FUNCTIONS IN: acetate-CoA ligase activity; INVOLVED IN: metabolic process, acetate metabolic process; LOCATED IN: cytosol, chloroplast stroma, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acetate--CoA ligase (InterPro:IPR011904), AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: acyl-activating enzyme 17 (TAIR:AT5G23050.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      14534585..14540441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123046.4 → NP_198504.1  acetyl-CoA synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ4
      Conserved Domains (2) summary
      cd05966
      Location:64 → 680
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PLN02654
      Location:29 → 693
      PLN02654; acetate-CoA ligase

    2. NM_001344154.1 → NP_001331094.1  acetyl-CoA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ4

    3. NM_001036897.3 → NP_001031974.2  acetyl-CoA synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031974.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGD6, O49063, Q9LTG4
      UniProtKB/TrEMBL
      A0A178UC31, A0A5S9YAV2
      Conserved Domains (1) summary
      PLN02654
      Location:79 → 743
      PLN02654; acetate-CoA ligase

    4. NM_001344155.1 → NP_001331096.1  acetyl-CoA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ4, A0A1P8BCV2

    5. NM_001344156.1 → NP_001331095.1  acetyl-CoA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ4

    6. NM_001344157.1 → NP_001331097.1  acetyl-CoA synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9DGD6.1

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