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    SMC3 structural maintenance of chromosome 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834917, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SMC3
    Official Full Name
    structural maintenance of chromosome 3
    Primary source
    TAIR:AT5G48600
    Locus tag
    AT5G48600
    See related
    Araport:AT5G48600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CHROMOSOME ASSOCIATED PROTEIN-C; ARABIDOPSIS THALIANA STRUCTURAL MAINTENANCE OF CHROMOSOME 4; ATCAP-C; ATSMC3; ATSMC4; K15N18.7; K15N18_7; structural maintenance of chromosome 3; STRUCTURAL MAINTENANCE OF CHROMOSOMES 3
    Summary
    member of SMC subfamily
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    Genomic context

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    See SMC3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    28
    Sequence:
    Chromosome: 5; NC_003076.8 (19701728..19709342)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FK506- and rapamycin-binding protein 15 kD-2 Neighboring gene phosphoserine aminotransferase, putative (DUF760) Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Putative membrane lipoprotein Neighboring gene myb-like protein X

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of Arabidopsis SMC4 identifies condensin as a corepressor of pericentromeric transposons and conditionally expressed genes. Wang J, et al. Genes Dev, 2017 Aug 1. PMID 28882854, Free PMC Article
    2. Disruption of the Arabidopsis SMC4 gene, AtCAP-C, compromises gametogenesis and embryogenesis. Siddiqui NU, et al. Planta, 2006 Apr. PMID 16482433
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. silencing of transposons in the pericentromeric heterochromatin of Arabidopsis thaliana requires SMC4.
      Title: Mutation of Arabidopsis SMC4 identifies condensin as a corepressor of pericentromeric transposons and conditionally expressed genes.
    2. results reveal a critical role for AtCAP-C during cell division
      Title: Disruption of the Arabidopsis SMC4 gene, AtCAP-C, compromises gametogenesis and embryogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124236.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    structural maintenance of chromosome 3
    NP_001190492.1
    • structural maintenance of chromosome 3 (SMC3); FUNCTIONS IN: transporter activity, ATP binding; INVOLVED IN: chromosome segregation, chromosome organization; LOCATED IN: chromosome, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMCs flexible hinge (InterPro:IPR010935), RecF/RecN/SMC protein, N-terminal (InterPro:IPR003395); BEST Arabidopsis thaliana protein match is: structural maintenance of chromosomes 2 (TAIR:AT5G62410.1).
    NP_199671.1
    • structural maintenance of chromosome 3 (SMC3); FUNCTIONS IN: transporter activity, ATP binding; INVOLVED IN: chromosome segregation, chromosome organization; LOCATED IN: chromosome, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMCs flexible hinge (InterPro:IPR010935), RecF/RecN/SMC protein, N-terminal (InterPro:IPR003395); BEST Arabidopsis thaliana protein match is: Structural maintenance of chromosomes (SMC) family protein (TAIR:AT3G54670.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19701728..19709342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203563.2 → NP_001190492.1  structural maintenance of chromosome 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178ULI7, A0A5S9YCQ3, F4K1S1
      Conserved Domains (5) summary
      cd03274
      Location:1135 → 1229
      ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
      smart00968
      Location:555 → 670
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:24 → 1232
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22980
      Location:241 → 380
      Csx12; CRISPR/Cas system-associated protein Cas9
      pfam07106
      Location:754 → 831
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    2. NM_124236.3 → NP_199671.1  structural maintenance of chromosome 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJL0
      UniProtKB/TrEMBL
      A0A178ULI7, A0A5S9YCQ3
      Conserved Domains (5) summary
      cd03274
      Location:1132 → 1226
      ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
      smart00968
      Location:555 → 670
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:24 → 1229
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22980
      Location:241 → 380
      Csx12; CRISPR/Cas system-associated protein Cas9
      pfam07106
      Location:754 → 835
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJL0.1

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