PRR3 pseudo-response regulator 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PRR3
Official Full Name: pseudo-response regulator 3
Primary source: TAIR:AT5G60100
Locus tag: AT5G60100
See related: Araport:AT5G60100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: APRR3; MGO3.8; MGO3_8; pseudo-response regulator 3
Summary: Encodes pseudo-response regulator 3 (APRR3/PRR3). PRR3 transcript levels vary in a circadian pattern with peak expression at dusk under long and short day conditions. PRR3 affects the period of the circadian clock and seedlings with reduced levels of PRR3 have shorter periods, based on transcriptional assays of clock-regulated genes. PRR3 is expressed in the vasculature of cotyledons and leaves where it may help stabilize the TOC1 protein by preventing interactions between TOC1 and the F-box protein ZTL.
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Genomic context

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See PRR3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 9

Sequence:: Chromosome: 5; NC_003076.8 (24197971..24201415, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBOHH and RBOHJ were specifically expressed in pollen and dynamically targeted to distinct and overlapping plasma membrane domains at the pollen tube tip. Functional loss of RBOHH and RBOHJ in homozygous double mutants resulted in reduced fertility.
Title: Pollen tube NAD(P)H oxidases act as a speed control to dampen growth rate oscillations during polarized cell growth.
The results suggested that SNPs at PRR3 and ABCF1 genes and the haplotype composed by SNPs at GNL1 and PRR3 between the HLA-A and HLA-C genes tended to predict Graves ophthalmology in a gender-dependent manner in patients with Graves disease in Taiwan.
Title: Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.
TOC1/PRR3 phosphorylation-dependent interaction may protect TOC1 from ZTL-mediated degradation, resulting in an enhanced amplitude of TOC1 cycling
Title: Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins.
These results indicate that PRR3 might function to modulate TOC1 stability by hindering ZTL-dependent TOC1 degradation.
Title: PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203646.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphorelay response regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in cytokinin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: pseudo-response regulator 3

NP_001190574.1

pseudo-response regulator 3 (PRR3); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 7 (TAIR:AT5G02810.1).

NP_001190575.1

pseudo-response regulator 3 (PRR3); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 7 (TAIR:AT5G02810.1).

NP_568919.1

pseudo-response regulator 3 (PRR3); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 7 (TAIR:AT5G02810.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24197971..24201415 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001345387.1 → NP_001331791.1 pseudo-response regulator 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C0SVU8, Q4PRK5, Q4PRK6, Q9LVG4

UniProtKB/TrEMBL

A0A654GCP5, A0A7G2FJG9

Conserved Domains (2) summary

pfam06203
Location:442 → 484

CCT; CCT motif

cd17582
Location:66 → 169

psREC_PRR; pseudo receiver domain of pseudo-response regulators
NM_001345386.1 → NP_001331790.1 pseudo-response regulator 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UJI5, A0A1P8BEW7
NM_125403.3 → NP_568919.1 pseudo-response regulator 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568919.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0SVU8, Q4PRK5, Q4PRK6, Q9LVG4

UniProtKB/TrEMBL

A0A654GCP5, A0A7G2FJG9

Conserved Domains (2) summary

pfam06203
Location:442 → 484

CCT; CCT motif

cd17582
Location:66 → 169

psREC_PRR; pseudo receiver domain of pseudo-response regulators
NM_001203645.2 → NP_001190574.1 pseudo-response regulator 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190574.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0SVU8, Q4PRK5, Q4PRK6, Q9LVG4

UniProtKB/TrEMBL

A0A654GCP5, A0A7G2FJG9

Conserved Domains (2) summary

pfam06203
Location:442 → 484

CCT; CCT motif

cd17582
Location:66 → 169

psREC_PRR; pseudo receiver domain of pseudo-response regulators
NM_001345388.1 → NP_001331792.1 pseudo-response regulator 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UJI5, A0A1P8BEW7
NM_001345389.1 → NP_001331789.1 pseudo-response regulator 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UJI5, A0A1P8BEW7
NM_001203646.1 → NP_001190575.1 pseudo-response regulator 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190575.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FJG9, F4JXG7

Conserved Domains (3) summary

COG0745
Location:65 → 175

OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]

cd00156
Location:67 → 182

REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

pfam06203
Location:469 → 511

CCT; CCT motif