EBF2 EIN3-binding F box protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: EBF2
Official Full Name: EIN3-binding F box protein 2
Primary source: TAIR:AT5G25350
Locus tag: AT5G25350
See related: Araport:AT5G25350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EIN3-binding F box protein 2; F18G18.90; F18G18_90
Summary: Arabidopsis thaliana EIN3-binding F-box protein 2 (EBF2) mRNA. Part of the SCF complex, it is located in the nucleus and is involved in the ethylene-response pathway.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See EBF2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (8794252..8797349, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
Title: The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
In response to light activation of phytochrome photoreceptors, EIN3-BINDING F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induced phosphorylation of PIF3.
Title: Light-Dependent Degradation of PIF3 by SCF(EBF1/2) Promotes a Photomorphogenic Response in Arabidopsis.
The light-activated association of phyB, EIN3, and EBF1/EBF2 proteins stimulates robust EIN3 degradation by SCF(EBF1/EBF2) E3 ligases. We reveal that phyB manipulates substrate-E3 ligase interactions in a light-dependent manner, thus directly controlling the stability of EIN3.
Title: The Red Light Receptor Phytochrome B Directly Enhances Substrate-E3 Ligase Interactions to Attenuate Ethylene Responses.
An ethylene signal elevates the levels of EIN3, which directly binds and activates the EBF2 gene promoter.
Title: Ethylene signaling in Arabidopsis involves feedback regulation via the elaborate control of EBF2 expression by EIN3.
Data show that through control of EIN3/EIL1 levels, EBF1 and EBF2 fine-tune ethylene responses by repressing signaling in the absence of hormone, dampening signaling at high concentrations, and promoting rapid recovery after ethylene levels dissipate.
Title: The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ha2183 (e-PCR)
- UniSTS:515504

NM_122444.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: EIN3-binding F box protein 2

NP_197917.1

EIN3-binding F box protein 2 (EBF2); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), Leucine-rich repeat, cysteine-containing subtype (InterPro:IPR006553); BEST Arabidopsis thaliana protein match is: EIN3-binding F box protein 1 (TAIR:AT2G25490.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8794252..8797349 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122444.4 → NP_197917.1 EIN3-binding F box protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197917.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q708Y0

UniProtKB/TrEMBL

A0A178U7J0

Conserved Domains (3) summary

cd09293
Location:138 → 268

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:169 → 194

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00646
Location:54 → 92

F-box; F-box domain