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    MYB66 myb domain protein 66 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831327, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB66
    Official Full Name
    myb domain protein 66
    Primary source
    TAIR:AT5G14750
    Locus tag
    AT5G14750
    See related
    Araport:AT5G14750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMYB66; myb domain protein 66; T9L3.50; T9L3_50; WER; WER1; WEREWOLF; WEREWOLF 1
    Summary
    Encodes a MyB-related protein containing R2 and R3 repeats, involved in root and hypocotyl epidermal cell fate determination. Loss of function mutations make extra root hairs. Nuclear localized protein is a positive regulator for expression of CAPRICE (CPC).
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    Genomic context

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    See MYB66 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (4763372..4764834, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene carbonic anhydrase 2 Neighboring gene L-aspartate oxidase Neighboring gene PPR repeat protein Neighboring gene formate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into target DNA recognition by R2R3-MYB transcription factors. Wang B, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31733060, Free PMC Article
    2. The WEREWOLF MYB protein directly regulates CAPRICE transcription during cell fate specification in the Arabidopsis root epidermis. Ryu KH, et al. Development, 2005 Nov. PMID 16207757
    3. Phosphatidic acid interacts with a MYB transcription factor and regulates its nuclear localization and function in Arabidopsis. Yao H, et al. Plant Cell, 2013 Dec. PMID 24368785, Free PMC Article
    4. WEREWOLF, a MYB-related protein in Arabidopsis, is a position-dependent regulator of epidermal cell patterning. Lee MM, et al. Cell, 1999 Nov 24. PMID 10589676
    5. WEREWOLF, a regulator of root hair pattern formation, controls flowering time through the regulation of FT mRNA stability. Seo E, et al. Plant Physiol, 2011 Aug. PMID 21653190, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of Arabidopsis WEREWOLF, an R2R3-MYB protein, in complex with its target DNA, has been reported.
      Title: Structural insights into target DNA recognition by R2R3-MYB transcription factors.
    2. TRN1 regulates the position-dependent cell fate determination by affecting WER expression in Arabidopsis root epidermis.
      Title: TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana.
    3. WER expressed ubiquitously in the root induced GL2 expression only in the root epidermis, whereas co-expression of WER and EGL3 induced GL2 expression in the corresponding tissues.
      Title: WEREWOLF and ENHANCER of GLABRA3 are interdependent regulators of the spatial expression pattern of GLABRA2 in Arabidopsis.
    4. Double mutant analysis reveal that wer and caprice (cpc) mutants, defective in core components of the epidermal patterning pathway, genetically interact with sab. This suggests that SAB may act on epidermal patterning upstream of WER and CPC.
      Title: SABRE is required for stabilization of root hair patterning in Arabidopsis thaliana.
    5. Phosphatidic acid interacts with werewolf (WER), a R2R3 MYB transcription factor involved in root hair formation.
      Title: Phosphatidic acid interacts with a MYB transcription factor and regulates its nuclear localization and function in Arabidopsis.
    6. AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.
      Title: Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity.
    7. MYB23, WER, and MYB23-WER chimeric protein have similar functions in respect to root hair formation.
      Title: Functional divergence of MYB-related genes, WEREWOLF and AtMYB23 in Arabidopsis.
    8. WER and CPC compete with one another to define cell fates in the Arabidopsis root epidermis.
      Title: Cell fate in the Arabidopsis root epidermis is determined by competition between WEREWOLF and CAPRICE.
    9. WER regulates not the transcription but the stability of FT mRNA.
      Title: WEREWOLF, a regulator of root hair pattern formation, controls flowering time through the regulation of FT mRNA stability.
    10. The functional relationship of the R2R3-type MYB gene WEREWOLF (WER) and the R3-type MYB gene CAPRICE (CPC), was analyzed.
      Title: Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343363.1
    NM_001343364.1
    NM_001343365.1
    NM_121479.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myb domain protein 66
    NP_196979.1
    • myb domain protein 66 (MYB66); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: myb domain protein 23 (TAIR:AT5G40330.1); Has 9181 Blast hits to 8410 proteins in 556 species: Archae - 0; Bacteria - 0; Metazoa - 822; Fungi - 534; Plants - 5944; Viruses - 3; Other Eukaryotes - 1878 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4763372..4764834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121479.3 → NP_196979.1  myb domain protein 66 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SEI0, Q9ZTD2
      UniProtKB/TrEMBL
      A0A178UJM1, A0A384KIP7, C0SVP6
      Conserved Domains (1) summary
      PLN03212
      Location:17 → 137
      PLN03212; Transcription repressor MYB5; Provisional

    2. NM_001343363.1 → NP_001331610.1  myb domain protein 66 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEE2, A0A7G2F9S1
      Conserved Domains (1) summary
      PLN03212
      Location:1 → 76
      PLN03212; Transcription repressor MYB5; Provisional

    3. NM_001343364.1 → NP_001331609.1  myb domain protein 66 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEE0

    4. NM_001343365.1 → NP_001331611.1  myb domain protein 66 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEE2, A0A7G2F9S1
      Conserved Domains (1) summary
      PLN03212
      Location:1 → 76
      PLN03212; Transcription repressor MYB5; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SEI0.1

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