U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ESD4 Cysteine proteinases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827269, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ESD4
    Official Full Name
    Cysteine proteinases superfamily protein
    Primary source
    TAIR:AT4G15880
    Locus tag
    AT4G15880
    See related
    Araport:AT4G15880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATESD4; DL3980W; EARLY IN SHORT DAYS 4; FCAALL.406
    Summary
    EARLY IN SHORT DAYS 4 Arabidopsis mutant shows extreme early flowering and alterations in shoot development. It encodes a SUMO protease, located predominantly at the periphery of the nucleus. Accelerates the transition from vegetative growth to flowering. Probably acts in the same pathway as NUA in affecting flowering time, vegetative and inflorescence development.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ESD4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (9012552..9016179)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene terpene synthase 1 Neighboring gene kinesin motor protein-like protein Neighboring gene binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates. Murtas G, et al. Plant Cell, 2003 Oct. PMID 14507998, Free PMC Article
    2. Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1. Hermkes R, et al. Planta, 2011 Jan. PMID 20922545, Free PMC Article
    3. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis. Xie B, et al. New Phytol, 2024 Jan. PMID 37786257,
    4. Activation of NLR-Mediated Autoimmunity in Arabidopsis Early in Short Days 4 Mutant. Huang X, et al. Front Plant Sci, 2022. PMID 35693184, Free PMC Article
    5. SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Colby T, et al. Plant Physiol, 2006 Sep. PMID 16920872, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
      Title: NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
    2. Two A. thaliana SUMO proteases showing close sequence similarity have distinct in vivo functions.
      Title: Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_117680.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cysteine proteinases superfamily protein
    NP_567478.1
    • EARLY IN SHORT DAYS 4 (ESD4); CONTAINS InterPro DOMAIN/s: Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro:IPR003653); BEST Arabidopsis thaliana protein match is: UB-like protease 1A (TAIR:AT3G06910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9012552..9016179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341077.1 → NP_001328371.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4F2, A0A654FPS3

    2. NM_117680.4 → NP_567478.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFG4, O23439, Q70G10, Q7DLT0, Q94F30
      UniProtKB/TrEMBL
      A0A654FPS3
      Conserved Domains (1) summary
      PLN03189
      Location:1 → 489
      PLN03189; Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94F30.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.