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    NDT1 NAD+ transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819362, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NDT1
    Official Full Name
    NAD+ transporter 1
    Primary source
    TAIR:AT2G47490
    Locus tag
    AT2G47490
    See related
    Araport:AT2G47490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NAD+ TRANSPORTER 1; ATNDT1; NAD+ transporter 1; T30B22.21
    Summary
    Encodes a chloroplast-localized NAD+ transporter that transports NAD+ in a counter exchange mode with ADP and AMP in vitro.
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    Genomic context

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    See NDT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (19486842..19489732)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DUF3511 domain protein, putative (DUF3511) Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene P-loop nucleoside triphosphate hydrolases superfamily protein with CH (Calponin Homology) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial NAD(+) transporter (NDT1) plays important roles in cellular NAD(+) homeostasis in Arabidopsis thaliana. de Souza Chaves I, et al. Plant J, 2019 Nov. PMID 31278825, Free PMC Article
    2. Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins. Palmieri F, et al. J Biol Chem, 2009 Nov 6. PMID 19745225, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial NAD+ carrier (NDT1) plays an important role in cellular NAD+ homeostasis in leaves. Impaired NDT1 function results in reduced pollen grain viability, tube growth and seed filling, seed germination and seedling establishment.
      Title: The mitochondrial NAD(+) transporter (NDT1) plays important roles in cellular NAD(+) homeostasis in Arabidopsis thaliana.
    2. NDT1 resides in chloroplasts, whereas NDT2 locates to mitochondria.
      Title: Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_130317.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within NAD transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within NAD transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAD+ transporter 1
    NP_566102.1
    • NAD+ transporter 1 (NDT1); CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108), Adenine nucleotide translocator 1 (InterPro:IPR002113); BEST Arabidopsis thaliana protein match is: NAD+ transporter 2 (TAIR:AT1G25380.1); Has 28896 Blast hits to 14510 proteins in 466 species: Archae - 0; Bacteria - 6; Metazoa - 12245; Fungi - 8541; Plants - 5076; Viruses - 8; Other Eukaryotes - 3020 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19486842..19489732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130317.3 → NP_566102.1  NAD+ transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22261, Q94JT4
      UniProtKB/TrEMBL
      A0A5S9X7U8, A0A654F2S5
      Conserved Domains (1) summary
      pfam00153
      Location:218 → 303
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22261.2

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