Ezhip EZH inhibitory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ezhipprovided by MGI
Official Full Name: EZH inhibitory proteinprovided by MGI
Primary source: MGI:MGI:2147968
See related: Ensembl:ENSMUSG00000073294 AllianceGenome:MGI:2147968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KIP75
Summary: Predicted to enable histone methyltransferase inhibitor activity. Acts upstream of or within chromatin organization and oocyte development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in axial skeleton and rib. Orthologous to human EZHIP (EZH inhibitory protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in ovary adult (RPKM 10.7) and testis adult (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 2.7 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (5993272..5995474, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (6081218..6083420, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Ezhip (EZH inhibitory protein) in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Study uncovers Ezhip as a regulator of chromatin landscape in gametes.
Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
Study revealed that CXORF67 contains a highly conserved "K27M-like" sequence that is necessary and sufficient to inhibit PRC2 activity and reduce cellular H3K27me3 levels. Biochemical and cell-based studies demonstrate that CXORF67 functions as a K27M-like peptidyl inhibitor of PRC2. Therefore, study propose the name EZHIP (Enhancer of Zeste Homologs Inhibitory Protein) as a more descriptive for the function of CXORF67.
Title: PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU023811 (e-PCR)
- UniSTS:181277

AU022751 (e-PCR)
- UniSTS:209492

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone methyltransferase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EZH inhibitory protein

Names: K27M-like inhibitor of PRC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033211.3 → NP_001028383.2 EZH inhibitory protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal segment in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

BX649475

Consensus CDS

CCDS52982.1

UniProtKB/TrEMBL

Q3UWZ4

Related

ENSMUSP00000099222.4, ENSMUST00000101698.4

Conserved Domains (1) summary

PRK06995
Location:174 → 263

flhF; flagellar biosynthesis protein FlhF
NM_001166433.1 → NP_001159905.1 EZH inhibitory protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

BX649475

Consensus CDS

CCDS52981.1

UniProtKB/Swiss-Prot

B1B0V2, Q3TL73, Q3UWZ4, Q497U5

Related

ENSMUSP00000114041.2, ENSMUST00000117544.2

Conserved Domains (2) summary

PHA03247
Location:128 → 502

PHA03247; large tegument protein UL36; Provisional

PRK06995
Location:295 → 384

flhF; flagellar biosynthesis protein FlhF