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    Camk1 calcium/calmodulin-dependent protein kinase I [ Mus musculus (house mouse) ]

    Gene ID: 52163, updated on 4-Jan-2025

    Summary

    Official Symbol
    Camk1provided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase Iprovided by MGI
    Primary source
    MGI:MGI:1098535
    See related
    Ensembl:ENSMUSG00000030272 AllianceGenome:MGI:1098535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camk; CaMKIalpha; D6Ertd263e
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Acts upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of protein export from nucleus; and protein phosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including bone; cardiovascular system; genitourinary system; nervous system; and retina. Orthologous to human CAMK1 (calcium/calmodulin dependent protein kinase I). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 35.3), frontal lobe adult (RPKM 32.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Camk1 in Genome Data Viewer
    Location:
    6 E3; 6 52.75 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113311085..113320883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113334124..113343922, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene copine family member IX Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene STARR-positive B cell enhancer ABC_E237 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene STARR-positive B cell enhancer ABC_E1326 Neighboring gene 8-oxoguanine DNA-glycosylase 1 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of protein binding  
    involved_in nervous system development  
    acts_upstream_of_or_within nucleocytoplasmic transport PubMed 
    acts_upstream_of_or_within nucleocytoplasmic transport PubMed 
    involved_in positive regulation of dendritic spine development  
    involved_in positive regulation of dendritic spine development  
    involved_in positive regulation of muscle cell differentiation  
    involved_in positive regulation of muscle cell differentiation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of protein export from nucleus PubMed 
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of synapse structural plasticity  
    involved_in positive regulation of synapse structural plasticity  
    involved_in positive regulation of syncytium formation by plasma membrane fusion  
    involved_in positive regulation of syncytium formation by plasma membrane fusion  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of muscle cell differentiation  
    involved_in regulation of muscle cell differentiation  
    involved_in regulation of protein binding  
    involved_in regulation of protein binding  
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in regulation of synapse organization  
    involved_in regulation of synapse organization  
    involved_in signal transduction  
    acts_upstream_of_or_within signal transduction PubMed 
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in glutamatergic synapse  
    located_in nucleus  
    is_active_in postsynaptic density  
    is_active_in postsynaptic density  

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1
    Names
    caM kinase I alpha
    caM-KI
    caMKI-alpha
    NP_598687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133926.2NP_598687.1  calcium/calmodulin-dependent protein kinase type 1

      See identical proteins and their annotated locations for NP_598687.1

      Status: VALIDATED

      Source sequence(s)
      AC155287
      Consensus CDS
      CCDS20415.1
      UniProtKB/Swiss-Prot
      Q91YS8
      UniProtKB/TrEMBL
      Q3UY68
      Related
      ENSMUSP00000032409.9, ENSMUST00000032409.15
      Conserved Domains (1) summary
      cd14167
      Location:16278
      STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113311085..113320883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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