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    Mrpl37 mitochondrial ribosomal protein L37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56281, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl37provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L37provided by RGD
    Primary source
    RGD:619820
    See related
    EnsemblRapid:ENSRNOG00000009078 AllianceGenome:RGD:619820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    L37mt; Rpml2; MRP-L37
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPL37 (mitochondrial ribosomal protein L37). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 257.6), Heart (RPKM 214.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl37 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127056679..127075000, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (121827892..121846187, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126656330..126666830, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102946 Neighboring gene single stranded DNA binding protein 3 Neighboring gene uncharacterized LOC134479027 Neighboring gene uncharacterized LOC120102947 Neighboring gene cytochrome b5 reductase-like Neighboring gene ribosomal protein L28, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Graack HR, et al. Biochemistry, 1999 Dec 14. PMID 10600119
    2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC94649

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL37
    Names
    39S ribosomal protein L37, mitochondrial
    ribosomal protein, mitochondrial, L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004235.2 → NP_001004235.1  large ribosomal subunit protein mL37 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004235.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6AXT0
      UniProtKB/TrEMBL
      A6JYQ1
      Related
      ENSRNOP00000012102.3, ENSRNOT00000012102.7
      Conserved Domains (1) summary
      pfam07147
      Location:218 → 385
      PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

    2. NM_001429866.1 → NP_001416795.1  large ribosomal subunit protein mL37 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2KA48

    3. NM_001429867.1 → NP_001416796.1  large ribosomal subunit protein mL37 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RNA

    1. NR_190823.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127056679..127075000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110683.2 → XP_038966611.1  large ribosomal subunit protein mL37 isoform X1

      Related
      ENSRNOP00000075257.1, ENSRNOT00000091165.3
      Conserved Domains (1) summary
      pfam07147
      Location:294 → 385
      PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

    2. XM_039110684.2 → XP_038966612.1  large ribosomal subunit protein mL37 isoform X2

      Conserved Domains (1) summary
      pfam07147
      Location:194 → 285
      PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

    RNA

    1. XR_005504533.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXT0.1 GenPept UniProtKB/Swiss-Prot:Q6AXT0

    Gene LinkOut

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