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    Eapp E2F-associated phosphoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299043, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eappprovided by RGD
    Official Full Name
    E2F-associated phosphoproteinprovided by RGD
    Primary source
    RGD:1309624
    See related
    EnsemblRapid:ENSRNOG00000004509 AllianceGenome:RGD:1309624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309624
    Summary
    Predicted to act upstream of or within negative regulation of transcription elongation by RNA polymerase II; positive regulation of cell population proliferation; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human EAPP (E2F associated phosphoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 166.2), Thymus (RPKM 150.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eapp in Genome Data Viewer
    Location:
    6q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (77879634..77929653, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72166486..72194357, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75561898..75589274, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 18 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134479386 Neighboring gene serine palmitoyltransferase, small subunit A Neighboring gene U6 spliceosomal RNA Neighboring gene centrin 4, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC120093206 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. Novy M, et al. Mol Biol Cell, 2005 May. PMID 15716352, Free PMC Article
    2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189134

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E2F-associated phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134987.1 → NP_001128459.1  E2F-associated phosphoprotein isoform 1

      See identical proteins and their annotated locations for NP_001128459.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168880
      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09, F7EM49
      Related
      ENSRNOP00000006030.6, ENSRNOT00000006030.8
      Conserved Domains (1) summary
      pfam10238
      Location:135 → 277
      Eapp_C; E2F-associated phosphoprotein

    2. NM_001434161.1 → NP_001421090.1  E2F-associated phosphoprotein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001434162.1 → NP_001421091.1  E2F-associated phosphoprotein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      77879634..77929653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261676.1 → XP_063117746.1  E2F-associated phosphoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09

    2. XM_006240100.5 → XP_006240162.1  E2F-associated phosphoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09, F7EM49
      Related
      ENSRNOP00000092269.1, ENSRNOT00000115754.2
      Conserved Domains (1) summary
      pfam10238
      Location:135 → 277
      Eapp_C; E2F-associated phosphoprotein

    3. XM_039111974.2 → XP_038967902.1  E2F-associated phosphoprotein isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106729.1: Suppressed sequence

      Description
      NM_001106729.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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