Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 |
PubMed
|
Nef
|
nef
|
HIV-1 Nef impairs IL-4/GM-CSF-stimulated THP-1 differentiation towards immature DCs, which leads to the lower levels of CD11C, CD40, and HLA-DR protein expression from the cell surface |
PubMed
|
|
nef
|
CD11C is significantly downregulated from the surface of HIV-1 Nef-expressing THP-1 monocytes compared to that from the surface of control cells |
PubMed
|
Vpr
|
vpr
|
A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, alpha X (ITGAX, complement component 3 receptor 4 subunit) expression by HIV-1 Vpr in Vpr transduced macrophages |
PubMed
|
matrix
|
gag
|
HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton |
PubMed
|
Go to the HIV-1, Human Interaction Database