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    HMG2 3-hydroxy-3-methylglutaryl-CoA reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816244, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMG2
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA reductase 2
    Primary source
    TAIR:AT2G17370
    Locus tag
    AT2G17370
    See related
    Araport:AT2G17370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-hydroxy-3-methylglutaryl-CoA reductase 2; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2; F5J6.1; F5J6_1; HMGR2
    Summary
    Encodes a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that is involved in the synthesis of sterol and triterpenoid compounds.
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    Genomic context

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    See HMG2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (7549702..7552260)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene beta-mannosyltransferase-like protein Neighboring gene Ribosomal protein S4 (RPS4A) family protein Neighboring gene associated protein 19 Neighboring gene ankyrin repeat-containing 2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. Ohyama K, et al. Chem Pharm Bull (Tokyo), 2007 Oct. PMID 17917299
    2. Expression of the Arabidopsis HMG2 gene, encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase, is restricted to meristematic and floral tissues. Enjuto M, et al. Plant Cell, 1995 May. PMID 7780305, Free PMC Article
    3. Complete blockage of the mevalonate pathway results in male gametophyte lethality. Suzuki M, et al. J Exp Bot, 2009. PMID 19363204, Free PMC Article
    4. Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme. Enjuto M, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302869, Free PMC Article
    5. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMG1 or HMG2 is required for male gametophyte development.
      Title: Complete blockage of the mevalonate pathway results in male gametophyte lethality.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127292.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isoprenoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within triterpenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxy-3-methylglutaryl-CoA reductase 2
    NP_179329.1
    • 3-hydroxy-3-methylglutaryl-CoA reductase 2 (HMG2); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: hydroxy methylglutaryl CoA reductase 1 (TAIR:AT1G76490.1); Has 2106 Blast hits to 2105 proteins in 886 species: Archae - 203; Bacteria - 937; Metazoa - 224; Fungi - 225; Plants - 261; Viruses - 1; Other Eukaryotes - 255 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7549702..7552260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127292.3 → NP_179329.1  3-hydroxy-3-methylglutaryl-CoA reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43256
      UniProtKB/TrEMBL
      A0A178VRN5, A0A5S9WYZ7
      Conserved Domains (1) summary
      cd00643
      Location:148 → 549
      HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43256.1

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