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    FAB1 fatty acid biosynthesis 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843835, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAB1
    Official Full Name
    fatty acid biosynthesis 1
    Primary source
    TAIR:AT1G74960
    Locus tag
    AT1G74960
    See related
    Araport:AT1G74960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS BETA-KETOACYL-ACP SYNTHETASE 2; ATKAS2; BETA-KETOACYL-ACP SYNTHETASE 2; F25A4.7; F25A4_7; fatty acid biosynthesis 1; KAS2
    Summary
    Encodes a plastidic beta-ketoacyl-ACP synthase II, involved in fatty acid elongation from 16:0-ACP to 18:0-ACP. Homozygous knock-out mutants are embryo lethal, indicating early embryo development is sensitive to elevated 16:0.
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    Genomic context

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    See FAB1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (28151920..28156350, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase, putative (DUF581) Neighboring gene TIFY domain/Divergent CCT motif family protein Neighboring gene ribosomal protein S9 Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Prokaryotic Pathway Rescue the fatty acid biosynthesis1 Mutant in the Cold. Gao J, et al. Plant Physiol, 2015 Sep. PMID 26224803, Free PMC Article
    2. Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana. Hakozaki H, et al. Genes Genet Syst, 2008 Apr. PMID 18506098
    3. A KAS2 cDNA complements the phenotypes of the Arabidopsis fab1 mutant that differs in a single residue bordering the substrate binding pocket. Carlsson AS, et al. Plant J, 2002 Mar. PMID 12148534
    4. A mutation in the LPAT1 gene suppresses the sensitivity of fab1 plants to low temperature. Kim HU, et al. Plant Physiol, 2010 Jul. PMID 20488893, Free PMC Article
    5. A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function. Barkan L, et al. Plant Physiol, 2006 Jul. PMID 16698898, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the identification of two suppressor mutations, one in act1, which encodes the chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1, which encodes the chloroplast acyl-ACP:lysophosphatidic acid acyltransferase, is reported..
      Title: Mutations in the Prokaryotic Pathway Rescue the fatty acid biosynthesis1 Mutant in the Cold.
    2. The suppressor mutation of fab1 was identified, by map-based and candidate-gene approaches, as a hypomorphic allele of lysophosphatidic acid acyltransferase1 (lpat1), lpat1-3.
      Title: A mutation in the LPAT1 gene suppresses the sensitivity of fab1 plants to low temperature.
    3. Results suggest that AtKAS2 is required for embryo development in Arabidopsis during the transition from the globular to the heart stage.
      Title: Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana.
    4. A change in shape of the major thylakoid lipid, monogalactosyldiacylglycerol, mediated by the fad5-2 mutation, may compensate for changes in lipid structure resulting from the original fab1 mutation.
      Title: A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198471.1
    NM_106154.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within unsaturated fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid biosynthesis 1
    NP_001185400.1
    • fatty acid biosynthesis 1 (FAB1); CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1).
    NP_565097.1
    • fatty acid biosynthesis 1 (FAB1); FUNCTIONS IN: 3-oxoacyl-[acyl-carrier-protein] synthase activity, fatty acid synthase activity; INVOLVED IN: fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1); Has 31012 Blast hits to 28002 proteins in 3663 species: Archae - 7; Bacteria - 21780; Metazoa - 495; Fungi - 2498; Plants - 402; Viruses - 1; Other Eukaryotes - 5829 (source: NCBI BLink).
    NP_849888.1
    • fatty acid biosynthesis 1 (FAB1); FUNCTIONS IN: 3-oxoacyl-[acyl-carrier-protein] synthase activity, fatty acid synthase activity; INVOLVED IN: fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1); Has 31012 Blast hits to 28002 proteins in 3663 species: Archae - 7; Bacteria - 21780; Metazoa - 495; Fungi - 2498; Plants - 402; Viruses - 1; Other Eukaryotes - 5829 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28151920..28156350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179557.4 → NP_849888.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849888.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
      UniProtKB/TrEMBL
      A0A5S9WUI4, A0A654EQM7
      Conserved Domains (1) summary
      PLN02787
      Location:3 → 541
      PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II

    2. NM_001198471.1 → NP_001185400.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
      UniProtKB/TrEMBL
      A0A5S9WUI4, A0A654EQM7
      Conserved Domains (1) summary
      PLN02787
      Location:3 → 541
      PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II

    3. NM_106154.4 → NP_565097.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
      UniProtKB/TrEMBL
      A0A5S9WUI4, A0A654EQM7
      Conserved Domains (1) summary
      PLN02787
      Location:3 → 541
      PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9P4.1

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