LGO LOSS OF GIANT CELLS FROM ORGANS [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: LGO
Official Full Name: LOSS OF GIANT CELLS FROM ORGANS
Primary source: TAIR:AT3G10525
Locus tag: AT3G10525
See related: Araport:AT3G10525
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: LOSS OF GIANT CELLS FROM ORGANS; SIAMESE RELATED 1; SMR1
Summary: Encodes LGO (loss of giant cells from organs) required for endoreduplication in sepal giant cell formation. Giant cells in both leaves and sepals are absent in lgo mutants. LGO is a member of a plant specific cell cycle inhibitor family SIAMESE and was originally named as SMR1(SIAMESE RELATED 1).
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Both the SIAMESE RELATED 1 (SMR1) transcript and SMR1 protein accumulate under moderate drought.
Title: SIAMESE-RELATED1 Is Regulated Posttranslationally and Participates in Repression of Leaf Growth under Moderate Drought.
SMR1 role in regulating cell-cycle progression and innate immunity
Title: Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in Arabidopsis.
SIM and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes. [SMR1]
Title: A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_111888.3

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sepal giant cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_566377.1

LOSS OF GIANT CELLS FROM ORGANS (LGO); BEST Arabidopsis thaliana protein match is: cyclin-dependent protein kinase inhibitors (TAIR:AT5G04470.1); Has 43 Blast hits to 43 proteins in 10 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 39; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).