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    PYRB PYRIMIDINE B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821577, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PYRB
    Official Full Name
    PYRIMIDINE B
    Primary source
    TAIR:AT3G20330
    Locus tag
    AT3G20330
    See related
    Araport:AT3G20330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PYRIMIDINE B
    Summary
    encodes aspartate carbamoyltransferase catalyzing the second step in the de novo pyrimidine ribonucleotide biosynthesis
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    Genomic context

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    See PYRB in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (7089989..7092670, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ethylene response factor 7 Neighboring gene trigalactosyldiacylglycerol2 Neighboring gene protein expression protein Neighboring gene actin cytoskeleton-regulatory complex pan-like protein Neighboring gene TRAF-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and functional analysis of aspartate transcarbamoylase and role of de novo pyrimidine synthesis in regulation of growth and development in Arabidopsis. Chen CT, et al. Plant Physiol Biochem, 2008 Feb. PMID 18053734
    2. Heterospecific cloning of Arabidopsis thaliana cDNAs by direct complementation of pyrimidine auxotrophic mutants of Saccharomyces cerevisiae. I. Cloning and sequence analysis of two cDNAs catalysing the second, fifth and sixth steps of the de novo pyrimidine biosynthesis pathway. Nasr F, et al. Mol Gen Genet, 1994 Jul 8. PMID 8041358
    3. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338476.1
    NM_112924.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate carbamoyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    PYRIMIDINE B
    NP_188668.1
    • PYRIMIDINE B (PYRB); FUNCTIONS IN: amino acid binding, protein binding, aspartate carbamoyltransferase activity, carboxyl- or carbamoyltransferase activity; INVOLVED IN: cellular response to phosphate starvation, pyrimidine ribonucleotide biosynthetic process, cellular amino acid metabolic process; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding (InterPro:IPR006132), Aspartate/ornithine carbamoyltransferase (InterPro:IPR006130), Aspartate carbamoyltransferase, eukaryotic (InterPro:IPR002082), Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain (InterPro:IPR006131); BEST Arabidopsis thaliana protein match is: ornithine carbamoyltransferase (TAIR:AT1G75330.1); Has 16843 Blast hits to 16841 proteins in 2894 species: Archae - 534; Bacteria - 10902; Metazoa - 218; Fungi - 284; Plants - 116; Viruses - 6; Other Eukaryotes - 4783 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7089989..7092670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112924.4 → NP_188668.1  PYRIMIDINE B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49077, Q683J9, Q94A47, Q9LTR1
      UniProtKB/TrEMBL
      A0A178VJE3, A0A654FHJ6
      Conserved Domains (1) summary
      PLN02527
      Location:85 → 390
      PLN02527; aspartate carbamoyltransferase

    2. NM_001338476.1 → NP_001326915.1  PYRIMIDINE B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49077, Q683J9, Q94A47, Q9LTR1
      UniProtKB/TrEMBL
      A0A178VJE3, A0A654FHJ6
      Conserved Domains (1) summary
      PLN02527
      Location:85 → 390
      PLN02527; aspartate carbamoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49077.2

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