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    MMD1 RING/FYVE/PHD zinc finger superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842932, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MMD1
    Official Full Name
    RING/FYVE/PHD zinc finger superfamily protein
    Primary source
    TAIR:AT1G66170
    Locus tag
    AT1G66170
    See related
    Araport:AT1G66170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F15E12.11; F15E12_11; MALE MEIOCYTE DEATH 1
    Summary
    encodes a PHD-domain containing protein required for male meiosis. Gene is expressed in developing male meiocytes and protein is localized to the nucleus.
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    Genomic context

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    See MMD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (24638685..24641494, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene transmembrane kinase 1 Neighboring gene CYS, MET, PRO, and GLY protein 1 Neighboring gene ncRNA Neighboring gene Eukaryotic aspartyl protease family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Hypomorphic Mutant of PHD Domain Protein Male Meiocytes Death 1. Liu B, et al. Genes (Basel), 2021 Apr 1. PMID 33916197, Free PMC Article
    2. The Arabidopsis MALE MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male meiosis. Yang X, et al. Plant Cell, 2003 Jun. PMID 12782723, Free PMC Article
    3. Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis. Wang J, et al. Nat Plants, 2020 Jul. PMID 32572214
    4. The PHD Finger Protein MMD1/DUET Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of the Condensin Gene CAP-D3. Wang J, et al. Plant Cell, 2016 Aug. PMID 27385818, Free PMC Article
    5. The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis. Andreuzza S, et al. PLoS Genet, 2015 Sep. PMID 26348709, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Hypomorphic Mutant of PHD Domain Protein Male Meiocytes Death 1.
      Title: A Hypomorphic Mutant of PHD Domain Protein Male Meiocytes Death 1.
    2. discoveries provide strong evidence that the histone reader MMD1/DUET defines an important step for regulating the progression of meiotic prophase I chromosome condensation.
      Title: The PHD Finger Protein MMD1/DUET Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of the Condensin Gene CAP-D3.
    3. results reveal the action of DUET as a transcriptional regulator during male meiosis in plants, and suggest that transcription of meiotic genes is under stagewise control in plants as in yeast
      Title: The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_105288.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables euchromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic spindle organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pollen sperm cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect positive regulation of chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/FYVE/PHD zinc finger superfamily protein
    NP_176791.2
    • MALE MEIOCYTE DEATH 1 (MMD1); FUNCTIONS IN: DNA binding, zinc ion binding; INVOLVED IN: microsporogenesis, regulation of transcription, DNA-dependent, male meiosis; LOCATED IN: nucleus; EXPRESSED IN: sperm cell, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: RING/FYVE/PHD zinc finger superfamily protein (TAIR:AT2G01810.1); Has 932 Blast hits to 913 proteins in 159 species: Archae - 0; Bacteria - 0; Metazoa - 337; Fungi - 321; Plants - 250; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24638685..24641494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105288.2 → NP_176791.2  RING/FYVE/PHD zinc finger superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176791.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7X6Y7, Q9C8D0
      UniProtKB/TrEMBL
      A0A178WI00
      Conserved Domains (1) summary
      cd15556
      Location:608 → 653
      PHD_MMD1_like; PHD finger found in Arabidopsis thaliana PHD finger protein MALE MEIOCYTE DEATH 1 (MMD1), PHD finger protein MALE STERILITY 1 (MS1), and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7X6Y7.1

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