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    ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 [ Homo sapiens (human) ]

    Gene ID: 55625, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZDHHC7provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 7provided by HGNC
    Primary source
    HGNC:HGNC:18459
    See related
    Ensembl:ENSG00000153786 MIM:614604; AllianceGenome:HGNC:18459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC7; SERZ1; SERZ-B; ZNF370
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including nuclear receptor-mediated steroid hormone signaling pathway; regulation of protein localization; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 20.6), lung (RPKM 20.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC7 in Genome Data Viewer
    Location:
    16q24.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84974175..85027631, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (91040795..91094281, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85007781..85045141, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein pseudogene Neighboring gene long intergenic non-protein coding RNA 2176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84981710-84982210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84982211-84982711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:85009937-85011136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85028227-85028727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85038209-85038959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:85045288-85046044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85068709-85069209 Neighboring gene KIAA0513 Neighboring gene Sharpr-MPRA regulatory region 15308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85100891-85101391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85110035-85110590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85111701-85112255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85115357-85116184 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85116185-85117012 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85117013-85117838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85121851-85122676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85124326-85125149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11263 Neighboring gene CBY1 interacting BAR domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer. Lin Z, et al. Oncogene, 2023 Jun. PMID 37198397
    2. Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. Rossin A, et al. Cell Death Differ, 2015 Apr. PMID 25301068, Free PMC Article
    3. Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner. Hohoff C, et al. Brain Struct Funct, 2019 Jul. PMID 31183559
    4. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. Tonn Eisinger KR, et al. J Biol Chem, 2018 Oct 12. PMID 30158247, Free PMC Article
    5. S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P, et al. J Biol Chem, 2017 Mar 31. PMID 28196865, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
      Title: Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
    2. demonstrated the importance of Zdhhc7 for assembling proper brain structure, function, and behavior on a system level in mice in a sex-related manner
      Title: Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.
    3. identified DHHC7 as a JAM-C palmitoylating enzyme
      Title: S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
    4. The ZDHHC7-mediated SCRIB palmitoylation is critical for SCRIB membrane targeting, cell polarity and tumor suppression, providing new mechanistic insights of how dynamic protein palmitoylation regulates cell polarity and tumorigenesis.
      Title: ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.
    5. DHHC7-mediated palmitoylation of Fas allows a proper Fas expression level by preventing its degradation through the lysosomes.
      Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.
    6. the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
      Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10792, FLJ20279

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose import in response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarized epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Fas signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell-cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC7
    Names
    DHHC-7
    Sertoli cell gene with zinc finger domain-I(2)
    Sertoli cell gene with zinc finger domain-beta
    acyltransferase ZDHHC7
    zinc finger DHHC domain-containing protein 7
    zinc finger DHHC-type containing 7
    zinc finger protein 370
    zinc finger, DHHC domain containing 7
    NP_001139020.1
    NP_060210.2
    XP_011521524.1
    XP_024306111.1
    XP_047290306.1
    XP_047290307.1
    XP_047290308.1
    XP_047290309.1
    XP_047290310.1
    XP_047290311.1
    XP_047290312.1
    XP_047290313.1
    XP_047290314.1
    XP_054169420.1
    XP_054169421.1
    XP_054169422.1
    XP_054169423.1
    XP_054169424.1
    XP_054169425.1
    XP_054169426.1
    XP_054169427.1
    XP_054169428.1
    XP_054169429.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145548.2 → NP_001139020.1  palmitoyltransferase ZDHHC7 isoform 1

      See identical proteins and their annotated locations for NP_001139020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC092341, AW235073, BC018772, DA507340
      Consensus CDS
      CCDS45538.1
      UniProtKB/Swiss-Prot
      Q9NXF8
      Related
      ENSP00000456782.1, ENST00000564466.5
      Conserved Domains (1) summary
      pfam01529
      Location:168 → 295
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_017740.3 → NP_060210.2  palmitoyltransferase ZDHHC7 isoform 2

      See identical proteins and their annotated locations for NP_060210.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a coding exon but maintains the reading frame compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC092341, AK000286, AW235073, CN427219, DA507340
      Consensus CDS
      CCDS10950.1
      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
      Related
      ENSP00000315604.5, ENST00000313732.9
      Conserved Domains (1) summary
      pfam01529
      Location:131 → 258
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      84974175..85027631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434355.1 → XP_047290311.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    2. XM_047434352.1 → XP_047290308.1  palmitoyltransferase ZDHHC7 isoform X1

    3. XM_047434353.1 → XP_047290309.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    4. XM_047434350.1 → XP_047290306.1  palmitoyltransferase ZDHHC7 isoform X1

    5. XM_047434356.1 → XP_047290312.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    6. XM_047434354.1 → XP_047290310.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    7. XM_047434351.1 → XP_047290307.1  palmitoyltransferase ZDHHC7 isoform X1

    8. XM_024450343.2 → XP_024306111.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
      Conserved Domains (1) summary
      pfam01529
      Location:131 → 258
      DHHC; DHHC palmitoyltransferase

    9. XM_047434358.1 → XP_047290314.1  palmitoyltransferase ZDHHC7 isoform X4

    10. XM_047434357.1 → XP_047290313.1  palmitoyltransferase ZDHHC7 isoform X3

    11. XM_011523222.3 → XP_011521524.1  palmitoyltransferase ZDHHC7 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      91040795..91094281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313449.1 → XP_054169424.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    2. XM_054313447.1 → XP_054169422.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    3. XM_054313445.1 → XP_054169420.1  palmitoyltransferase ZDHHC7 isoform X1

    4. XM_054313450.1 → XP_054169425.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    5. XM_054313446.1 → XP_054169421.1  palmitoyltransferase ZDHHC7 isoform X1

    6. XM_054313448.1 → XP_054169423.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    7. XM_054313451.1 → XP_054169426.1  palmitoyltransferase ZDHHC7 isoform X2

      UniProtKB/Swiss-Prot
      D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

    8. XM_054313453.1 → XP_054169428.1  palmitoyltransferase ZDHHC7 isoform X4

    9. XM_054313454.1 → XP_054169429.1  palmitoyltransferase ZDHHC7 isoform X4

    10. XM_054313452.1 → XP_054169427.1  palmitoyltransferase ZDHHC7 isoform X3

    RNA

    1. XR_008484706.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXF8.2 GenPept UniProtKB/Swiss-Prot:Q9NXF8

    Gene LinkOut

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