Cntd1 cyclin N-terminal domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cntd1provided by MGI
Official Full Name: cyclin N-terminal domain containing 1provided by MGI
Primary source: MGI:MGI:1923965
See related: Ensembl:ENSMUSG00000078653 AllianceGenome:MGI:1923965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cntd; 1700051C09Rik; 4921513J16Rik; 5430417M23Rik
Summary: Involved in regulation of meiotic cell cycle. Acts upstream of or within reciprocal meiotic recombination and spermatogenesis. Located in chromosome. Orthologous to human CNTD1 (cyclin N-terminal domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 20.6), bladder adult (RPKM 6.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 64.56 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101170029..101179527)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101279203..101288701)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
Title: Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
CNTD1 has a critical role in meiotic crossover maturation and deselection of excess precrossover sites
Title: Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126156 (e-PCR)
- UniSTS:162867

RH127824 (e-PCR)
- UniSTS:211134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin N-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026562.2 → NP_080838.1 cyclin N-terminal domain-containing protein 1

See identical proteins and their annotated locations for NP_080838.1

Status: PROVISIONAL

Source sequence(s)

AK007245

Consensus CDS

CCDS25461.1

UniProtKB/Swiss-Prot

Q9D995, Q9D9L8

Related

ENSMUSP00000099396.5, ENSMUST00000103107.5

Conserved Domains (1) summary

cl00050
Location:57 → 180

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...