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    Mnd1 meiotic nuclear divisions 1 [ Mus musculus (house mouse) ]

    Gene ID: 76915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mnd1provided by MGI
    Official Full Name
    meiotic nuclear divisions 1provided by MGI
    Primary source
    MGI:MGI:1924165
    See related
    Ensembl:ENSMUSG00000033752 AllianceGenome:MGI:1924165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gaj; 2610034E18Rik
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and reciprocal meiotic recombination. Predicted to be located in nucleus. Is expressed in branchial arch; central nervous system; embryo; forelimb bud; and somite. Orthologous to human MND1 (meiotic nuclear divisions 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 3.5), CNS E11.5 (RPKM 3.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mnd1 in Genome Data Viewer
    Location:
    3 F1; 3 37.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83995240..84063084, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84087933..84155798, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352 Neighboring gene STARR-positive B cell enhancer ABC_E3440 Neighboring gene predicted gene, 30458 Neighboring gene STARR-positive B cell enhancer ABC_E7917 Neighboring gene STARR-positive B cell enhancer ABC_E9214 Neighboring gene STARR-positive B cell enhancer ABC_E1020 Neighboring gene STARR-seq mESC enhancer starr_08077 Neighboring gene tripartite motif-containing 2 Neighboring gene STARR-seq mESC enhancer starr_08078 Neighboring gene ribosomal protein L36a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:84032505-84032806 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange. Pezza RJ, et al. Biophys J, 2010 Dec 1. PMID 21112301, Free PMC Article
    2. The dual role of HOP2 in mammalian meiotic homologous recombination. Pezza RJ, et al. Nucleic Acids Res, 2014 Feb. PMID 24304900, Free PMC Article
    3. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Zhao W, et al. Nucleic Acids Res, 2014 Jan. PMID 24150939, Free PMC Article
    4. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. Pezza RJ, et al. J Biol Chem, 2006 Jul 7. PMID 16675459
    5. A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice. Tran TN, et al. Mol Hum Reprod, 2019 Oct 28. PMID 31393579, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assuming the mouse model accurately reflects the impact of this variant in humans, rs140107488 appears to be a benign allele that can be eliminated or de-prioritized in clinical genomic analyses of infertility patients.
      Title: A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice.
    2. HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
      Title: HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.
    3. The Hop2-Mnd1 heterodimer efficiently condenses double-stranded DNA via formation of a bright spot or DNA condensate.
      Title: Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange.
    4. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
      Title: Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
    5. Characterization of the MND1 gene in Saccharomyces cerevisiae and identification of a potential homolog in mouse.
      Title: The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.
    6. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis [Mnd1]
      Title: The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    meiotic nuclear division protein 1 homolog
    Names
    meiotic nuclear divisions 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398662.1 → NP_001385591.1  meiotic nuclear division protein 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154875
      Conserved Domains (1) summary
      COG5124
      Location:5 → 179
      COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]

    2. NM_029797.4 → NP_084073.2  meiotic nuclear division protein 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_084073.2

      Status: VALIDATED

      Source sequence(s)
      AC154875
      Consensus CDS
      CCDS38464.1
      UniProtKB/Swiss-Prot
      Q8K396, Q9D0A1
      Related
      ENSMUSP00000048262.7, ENSMUST00000047368.8
      Conserved Domains (2) summary
      COG5124
      Location:5 → 204
      COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
      pfam03962
      Location:16 → 202
      Mnd1; Mnd1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      83995240..84063084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163403.1 → XP_036019296.1  meiotic nuclear division protein 1 homolog isoform X1

      Conserved Domains (1) summary
      COG5124
      Location:1 → 189
      COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K396.1 GenPept UniProtKB/Swiss-Prot:Q8K396

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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