Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc9b2provided by MGI
Official Full Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2provided by MGI
Primary source: MGI:MGI:2140077
See related: Ensembl:ENSMUSG00000037994 AllianceGenome:MGI:2140077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NHA2; NHE10; nhaoc; Nhedc2; nha-oc
Summary: Predicted to enable identical protein binding activity; lithium:proton antiporter activity; and sodium:proton antiporter activity. Involved in several processes, including flagellated sperm motility; regulation of insulin secretion involved in cellular response to glucose stimulus; and sodium ion homeostasis. Acts upstream of or within positive regulation of osteoclast development. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and sperm principal piece. Is expressed in alimentary system; brain; femur; male reproductive gland or organ; and mesenteric adipose tissue. Orthologous to human SLC9B2 (solute carrier family 9 member B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 62.55 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (135013083..135048606)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (135307651..135342845)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that dietary salt elevates NHA2 expression in the nephron; NHA2 expression is localized apically to distal convoluted tubules and connecting tubules in the nephron; NHA2 expression in the nephron partially overlaps in distribution with V-type ATPase.
Title: NHA2 is expressed in distal nephron and regulated by dietary sodium.
data revealed that NHA1 and NHA2 function as a key sodium-hydrogen exchanger responsible for sperm motility after leaving the cauda epididymidis.
Title: Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility.
Data indicate a critical role of the endosomal sodium/hydrogen exchanger NHA2 for clathrin-mediated endocytosis and insulin secretion in beta-cells.
Title: Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells.
Data show evidence that NHEDC2 regulates osteoclastogenesis, an exhaustive analysis shows that Nhedc2GT/GT mice have no defect in osteoclast formation or function in vitro or in vivo.
Title: The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.
These data from NHA2-deficient mice suggest that NHA2 is dispensable for osteoclast differentiation and bone resorption both in vitro and in vivo.
Title: Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.
NHA-oc/NHA2 displays the expected activities of a bona fide cation-proton antiporter and plays a key role(s) in normal osteoclast differentiation and function
Title: NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts.
nha-oc is expressed by terminally differentiated osteoclasts.
Title: Expression analysis of nha-oc/NHA2: a novel gene selectively expressed in osteoclasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488997

NoName (e-PCR)
- UniSTS:234828

C80638 (e-PCR)
- UniSTS:165298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lithium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables lithium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lithium ion transport	IEA Inferred from Electronic Annotation more info
involved_in lithium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoclast development	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
NOT located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in sperm principal piece	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium/hydrogen exchanger 9B2

Names: NHE domain-containing protein 2; Na(+)/H(+) exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; Na+/H+ exchanger domain containing 2; mitochondrial Na(+)/H(+) exchanger NHA2; mitochondrial sodium/hydrogen exchanger 9B2; mitochondrial sodium/hydrogen exchanger NHA2; soditlum/hydrogen exchanger-like domain-containing protein 2; sodium/hydrogen exchanger-like domain-containing protein 2; solute carrier family 9 subfamily B member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411266.1 → NP_001398195.1 sodium/hydrogen exchanger 9B2 isoform 2

Status: VALIDATED

Source sequence(s)

AC104874
NM_001411267.1 → NP_001398196.1 sodium/hydrogen exchanger 9B2 isoform 3

Status: VALIDATED

Source sequence(s)

AC104874

Related

ENSMUST00000126034.4
NM_178877.7 → NP_849208.4 sodium/hydrogen exchanger 9B2 isoform 1

See identical proteins and their annotated locations for NP_849208.4

Status: VALIDATED

Source sequence(s)

AC104874

Consensus CDS

CCDS17854.1

UniProtKB/Swiss-Prot

Q5BKR2, Q8CA47, Q8CDX4

Related

ENSMUSP00000060640.8, ENSMUST00000051849.10

Conserved Domains (1) summary

cl01133
Location:176 → 534

Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

135013083..135048606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163428.1 → XP_036019321.1 sodium/hydrogen exchanger 9B2 isoform X3

Conserved Domains (1) summary

cl01133
Location:84 → 442

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_030252930.1 → XP_030108790.1 sodium/hydrogen exchanger 9B2 isoform X4

Conserved Domains (1) summary

cl01133
Location:18 → 285

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_006502400.5 → XP_006502463.1 sodium/hydrogen exchanger 9B2 isoform X2

Conserved Domains (1) summary

cl01133
Location:176 → 534

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_006502398.3 → XP_006502461.1 sodium/hydrogen exchanger 9B2 isoform X1

See identical proteins and their annotated locations for XP_006502461.1

UniProtKB/Swiss-Prot

Q5BKR2, Q8CA47, Q8CDX4

Conserved Domains (1) summary

cl01133
Location:176 → 534

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_006502402.3 → XP_006502465.1 sodium/hydrogen exchanger 9B2 isoform X4

Conserved Domains (1) summary

cl01133
Location:18 → 285

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_006502399.3 → XP_006502462.1 sodium/hydrogen exchanger 9B2 isoform X1

See identical proteins and their annotated locations for XP_006502462.1

UniProtKB/Swiss-Prot

Q5BKR2, Q8CA47, Q8CDX4

Conserved Domains (1) summary

cl01133
Location:176 → 534

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_030252931.1 → XP_030108791.1 sodium/hydrogen exchanger 9B2 isoform X4

Conserved Domains (1) summary

cl01133
Location:18 → 285

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_036163430.1 → XP_036019323.1 sodium/hydrogen exchanger 9B2 isoform X4

Conserved Domains (1) summary

cl01133
Location:18 → 285

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_036163431.1 → XP_036019324.1 sodium/hydrogen exchanger 9B2 isoform X4

Conserved Domains (1) summary

cl01133
Location:18 → 285

Na_H_Exchanger; Sodium/hydrogen exchanger family