Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pkmyt1provided by MGI
Official Full Name: protein kinase, membrane associated tyrosine/threonine 1provided by MGI
Primary source: MGI:MGI:2137630
See related: Ensembl:ENSMUSG00000023908 AllianceGenome:MGI:2137630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myt1; 6230424P17
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; early embryo; oocyte; retina; and thymus primordium. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 44.6), testis adult (RPKM 32.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.02 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (23945385..23955709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23726336..23736735)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
Title: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237586

AW209059 (e-PCR)
- UniSTS:166031

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Names: MYT1 kinase

NP_001405406.1

EC 2.7.11.1

NP_001405409.1

EC 2.7.11.1

NP_001405413.1

EC 2.7.11.1

NP_001405414.1

EC 2.7.11.1

NP_001405456.1

EC 2.7.11.1

NP_001405457.1

EC 2.7.11.1

NP_001405458.1

EC 2.7.11.1

NP_075545.2

EC 2.7.11.1

XP_006524373.1

EC 2.7.11.1

XP_006524374.1

EC 2.7.11.1

XP_030105683.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418477.1 → NP_001405406.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418480.1 → NP_001405409.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418484.1 → NP_001405413.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418485.1 → NP_001405414.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 5

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418527.1 → NP_001405456.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 6

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418528.1 → NP_001405457.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 7

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418529.1 → NP_001405458.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 8

Status: VALIDATED

Source sequence(s)

AC122821
NM_023058.4 → NP_075545.2 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

See identical proteins and their annotated locations for NP_075545.2

Status: VALIDATED

Source sequence(s)

AC122821

Consensus CDS

CCDS28460.1

UniProtKB/Swiss-Prot

Q3TNN2, Q8R3L4, Q9ESG9

Related

ENSMUSP00000024701.8, ENSMUST00000024701.9

Conserved Domains (2) summary

smart00220
Location:101 → 350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:99 → 348

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

23945385..23955709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524310.4 → XP_006524373.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

Conserved Domains (1) summary

cd14050
Location:148 → 397

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_006524311.5 → XP_006524374.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

Conserved Domains (1) summary

cd14050
Location:148 → 397

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_030249823.2 → XP_030105683.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 216

PKc_like; Protein Kinases, catalytic domain