Hepacam2 HEPACAM family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hepacam2provided by MGI
Official Full Name: HEPACAM family member 2provided by MGI
Primary source: MGI:MGI:2141520
See related: Ensembl:ENSMUSG00000044156 AllianceGenome:MGI:2141520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be involved in centrosome cycle. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be active in Golgi apparatus; microtubule cytoskeleton; and midbody. Is expressed in brain and foregut-midgut junction. Orthologous to human HEPACAM2 (HEPACAM family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 18.5), large intestine adult (RPKM 13.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.8 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (3457202..3498319, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (3457089..3498322, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

AI987662 (e-PCR)
- UniSTS:165450

Hepacam2 (e-PCR), detects polymorphism
- UniSTS:525496

NoName (e-PCR)
- UniSTS:488179

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: HEPACAM family member 2

Names: mitotic kinetics regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411485.1 → NP_001398414.1 HEPACAM family member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC022453, AC027655
NM_178899.6 → NP_849230.1 HEPACAM family member 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_849230.1

Status: VALIDATED

Source sequence(s)

AC022453

Consensus CDS

CCDS39414.1

UniProtKB/Swiss-Prot

Q4VAH7

Related

ENSMUSP00000058882.8, ENSMUST00000049985.15

Conserved Domains (3) summary

PHA02826
Location:184 → 322

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:167 → 233

Ig; Immunoglobulin domain

cl11960
Location:36 → 143

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

3457202..3498319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504960.3 → XP_006505023.1 HEPACAM family member 2 isoform X6

See identical proteins and their annotated locations for XP_006505023.1

Conserved Domains (3) summary

PHA02826
Location:108 → 246

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:91 → 157

Ig; Immunoglobulin domain

cl11960
Location:30 → 99

Ig; Immunoglobulin domain
XM_030255044.2 → XP_030110904.1 HEPACAM family member 2 isoform X6

Conserved Domains (3) summary

PHA02826
Location:108 → 246

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:91 → 157

Ig; Immunoglobulin domain

cl11960
Location:30 → 99

Ig; Immunoglobulin domain
XM_006504958.3 → XP_006505021.1 HEPACAM family member 2 isoform X4

Conserved Domains (3) summary

PHA02826
Location:183 → 321

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:166 → 232

Ig; Immunoglobulin domain

cl11960
Location:35 → 142

Ig; Immunoglobulin domain
XM_006504957.3 → XP_006505020.1 HEPACAM family member 2 isoform X1

Related

ENSMUST00000201276.2

Conserved Domains (2) summary

cd00096
Location:168 → 234

Ig; Immunoglobulin domain

cl11960
Location:37 → 144

Ig; Immunoglobulin domain
XM_030255043.1 → XP_030110903.1 HEPACAM family member 2 isoform X5

Conserved Domains (3) summary

PHA02826
Location:183 → 321

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:166 → 232

Ig; Immunoglobulin domain

cl11960
Location:35 → 142

Ig; Immunoglobulin domain
XM_030255042.1 → XP_030110902.1 HEPACAM family member 2 isoform X3

UniProtKB/Swiss-Prot

Q4VAH7

Conserved Domains (3) summary

PHA02826
Location:184 → 322

PHA02826; IL-1 receptor-like protein; Provisional

cd00096
Location:167 → 233

Ig; Immunoglobulin domain

cl11960
Location:36 → 143

Ig; Immunoglobulin domain
XM_030255041.1 → XP_030110901.1 HEPACAM family member 2 isoform X2

Conserved Domains (2) summary

cd00096
Location:168 → 234

Ig; Immunoglobulin domain

cl11960
Location:37 → 144

Ig; Immunoglobulin domain