Abr active BCR-related gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abrprovided by MGI
Official Full Name: active BCR-related geneprovided by MGI
Primary source: MGI:MGI:107771
See related: Ensembl:ENSMUSG00000017631 AllianceGenome:MGI:107771
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including negative regulation of macrophage migration; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Located in cytosol and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including gut; mesothelium; metanephros; nervous system; and sensory organ. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 53.0), cortex adult (RPKM 47.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76307560..76468515, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76416732..76623324, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
Title: Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase.
Loss of abr expression causes defects in spine development.
Title: Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.
These results identify Abr-regulated CD4(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice.
Title: Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.
Bcr and Abr play a critical role in down-regulating hypoxia-induced pulmonary hypertension by deactivating Rac1.
Title: Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice.
These data show that Abr and Bcr normally curb very specific functions of mature tissue innate immune cells.
Title: Bcr and Abr cooperate in negatively regulating acute inflammatory responses.
These results identify Abr and Bcr as the only GTPase-activating proteins to date that specifically negatively regulate Rac function in vivo in primary macrophages.
Title: Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.
Abr and Bcr play important complementary roles during vestibular morphogenesis
Title: Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit322 (e-PCR), detects polymorphism
- UniSTS:126535

NoName (e-PCR)
- UniSTS:236642

NoName (e-PCR)
- UniSTS:236645

AU042359 (e-PCR)
- UniSTS:160122

D11Jcs13 (e-PCR), detects polymorphism
- UniSTS:461959

AI853502 (e-PCR)
- UniSTS:165775

Abr (e-PCR), detects polymorphism
- UniSTS:140999

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of macrophage migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neutrophil degranulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neutrophil degranulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: active breakpoint cluster region-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291186.2 → NP_001278115.1 active breakpoint cluster region-related protein isoform 4

See identical proteins and their annotated locations for NP_001278115.1

Status: VALIDATED

Source sequence(s)

AL591143, AL663050

Consensus CDS

CCDS70246.1

UniProtKB/Swiss-Prot

Q5SSL4

Related

ENSMUSP00000068982.8, ENSMUST00000065028.14

Conserved Domains (4) summary

cd08686
Location:288 → 408

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd04387
Location:427 → 622

RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...

cd13366
Location:59 → 242

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

cl02571
Location:17 → 65

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
NM_001346670.2 → NP_001333599.1 active breakpoint cluster region-related protein isoform 5

Status: VALIDATED

Source sequence(s)

AL591143, AL663050

Consensus CDS

CCDS83843.1

UniProtKB/Swiss-Prot

Q5SSL4

Related

ENSMUSP00000104045.3, ENSMUST00000108408.9
NM_001363379.2 → NP_001350308.1 active breakpoint cluster region-related protein isoform 6

Status: VALIDATED

Source sequence(s)

AL663050

Conserved Domains (2) summary

cd04387
Location:102 → 297

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cl14603
Location:55 → 83

C2; C2 domain
NM_198018.3 → NP_932135.1 active breakpoint cluster region-related protein isoform 1

See identical proteins and their annotated locations for NP_932135.1

Status: VALIDATED

Source sequence(s)

AL591143, AL663050

Consensus CDS

CCDS36231.1

UniProtKB/TrEMBL

A0A2X0U2A7

Related

ENSMUSP00000091551.5, ENSMUST00000094012.11

Conserved Domains (4) summary

cd08686
Location:518 → 638

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:104 → 294

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:657 → 852

RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...

cd13366
Location:289 → 472

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
NM_198894.3 → NP_942597.1 active breakpoint cluster region-related protein isoform 2

Status: VALIDATED

Source sequence(s)

AL591143, AL663050

Consensus CDS

CCDS25067.1

UniProtKB/TrEMBL

E9PUE7

Conserved Domains (4) summary

cd08686
Location:460 → 580

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd04387
Location:599 → 794

RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...

cd13366
Location:231 → 414

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

pfam00621
Location:49 → 237

RhoGEF; RhoGEF domain
NM_198895.3 → NP_942598.1 active breakpoint cluster region-related protein isoform 3

See identical proteins and their annotated locations for NP_942598.1

Status: VALIDATED

Source sequence(s)

AL591143, AL663050

Consensus CDS

CCDS25066.1

UniProtKB/Swiss-Prot

Q3U5G0, Q3UQJ6, Q3UY38, Q5SSL4, Q5SYJ5, Q5SYJ7, Q5SYJ8, Q5SYJ9, Q6PCY1, Q6PDH3

Related

ENSMUSP00000072522.7, ENSMUST00000072740.13

Conserved Domains (4) summary

cd08686
Location:506 → 626

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd04387
Location:645 → 840

RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...

cd13366
Location:277 → 460

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

pfam00621
Location:95 → 283

RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

76307560..76468515 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245469.1 → XP_030101329.1 active breakpoint cluster region-related protein isoform X1

Conserved Domains (4) summary

cd08686
Location:473 → 593

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:84 → 249

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:612 → 807

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:244 → 427

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_036156228.1 → XP_036012121.1 active breakpoint cluster region-related protein isoform X2

Conserved Domains (3) summary

cd00160
Location:92 → 282

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13366
Location:277 → 460

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

cl14603
Location:506 → 597

C2; C2 domain