Cpa1 carboxypeptidase A1, pancreatic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpa1provided by MGI
Official Full Name: carboxypeptidase A1, pancreaticprovided by MGI
Primary source: MGI:MGI:88478
See related: Ensembl:ENSMUSG00000054446 AllianceGenome:MGI:88478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpa; 0910001L12Rik
Summary: This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016]
Expression: Biased expression in small intestine adult (RPKM 1152.1), spleen adult (RPKM 853.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (30639217..30645360)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (30639218..30645361)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We generated a novel CPA1 N256K knock-in mouse strain, which carries the most frequently occurring human CPA1 p.N256K mutation in the mouse Cpa1 gene. The CPA1 N256K mice develop spontaneous and progressive chronic pancreatitis and exhibit signs of endoplasmic reticulum stress in their pancreas.
Title: Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice.
Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.
Title: Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

Cpa (e-PCR), detects polymorphism
- UniSTS:141387

Cpa (e-PCR), detects polymorphism
- UniSTS:141388

Cpa1 (e-PCR), detects polymorphism
- UniSTS:468827

Cpa1 (e-PCR), detects polymorphism
- UniSTS:547505

RH129113 (e-PCR)
- UniSTS:212421

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables exopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxypeptidase A1

NP_079626.2

EC 3.4.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025350.4 → NP_079626.2 carboxypeptidase A1 preproprotein

See identical proteins and their annotated locations for NP_079626.2

Status: REVIEWED

Source sequence(s)

AC155656, BC052661

Consensus CDS

CCDS19977.1

UniProtKB/Swiss-Prot

Q7TPZ8

Related

ENSMUSP00000031806.10, ENSMUST00000031806.10

Conserved Domains (2) summary

cd03870
Location:117 → 417

M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup

pfam02244
Location:27 → 99

Propep_M14; Carboxypeptidase activation peptide