Atf7 activating transcription factor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atf7provided by MGI
Official Full Name: activating transcription factor 7provided by MGI
Primary source: MGI:MGI:2443472
See related: Ensembl:ENSMUSG00000099083 AllianceGenome:MGI:2443472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110012F10Rik; 9430065F09Rik; C130020M04Rik
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Involved in several processes, including hematopoietic progenitor cell differentiation; hepatocyte apoptotic process; and p38MAPK cascade. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human ATF7 (activating transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 18.6), limb E14.5 (RPKM 18.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 57.66 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102434381..102533899, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102525946..102625464, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m[5] C Methylation of Atf7 mRNA.
Title: HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m(5) C Methylation of Atf7 mRNA.
ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
Title: ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
Title: ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
ATF7 is involved in regulating lifespan and stress-induced senescence via p16Ink4a gene transcription.
Title: Stress-induced and ATF7-dependent epigenetic change influences cellular senescence.
Here, we show that TNF-alpha, which is induced by various psychological stresses, induces the p38-dependent phosphorylation of ATF7, a stress-responsive chromatin regulator, in mouse testicular germ cells. This caused a release of ATF7 from the TERRA gene promoter in the subtelomeric region, which disrupted heterochromatin and induced TERRA.
Title: Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7.
A decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice.
Title: ATF7 mediates TNF-α-induced telomere shortening.
ATF7 ablation prevents diet-induced obesity and insulin resistance.
Title: ATF7 ablation prevents diet-induced obesity and insulin resistance.
ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei.
Title: Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

BE225843 (e-PCR)
- UniSTS:209151

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hepatocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-7

Names: cAMP-dependent transcription factor ATF-7; transcription factor ATF-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310066.1 → NP_001296995.1 cyclic AMP-dependent transcription factor ATF-7 isoform 1

See identical proteins and their annotated locations for NP_001296995.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Both variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC123870, AC137156, AK039648, AK164412

Consensus CDS

CCDS84198.1

UniProtKB/Swiss-Prot

Q8R0S1

UniProtKB/TrEMBL

Q3TZR9, Q3U2X8

Related

ENSMUSP00000139308.2, ENSMUST00000184485.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001310067.1 → NP_001296996.1 cyclic AMP-dependent transcription factor ATF-7 isoform 1

See identical proteins and their annotated locations for NP_001296996.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC123870, AC137156, AK039648, AK164412

Consensus CDS

CCDS84198.1

UniProtKB/Swiss-Prot

Q8R0S1

UniProtKB/TrEMBL

Q3TZR9, Q3U2X8

Related

ENSMUSP00000139181.2, ENSMUST00000184616.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001310070.1 → NP_001296999.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC123870, AK047901, AK164412

Consensus CDS

CCDS84197.1

UniProtKB/Swiss-Prot

Q8R0S1

UniProtKB/TrEMBL

Q3U2X8, V9GXN6

Related

ENSMUSP00000139243.2, ENSMUST00000184906.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102434381..102533899 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_146065.1: Suppressed sequence

Description

NM_146065.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.