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    Slc25a38 solute carrier family 25, member 38 [ Mus musculus (house mouse) ]

    Gene ID: 208638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a38provided by MGI
    Official Full Name
    solute carrier family 25, member 38provided by MGI
    Primary source
    MGI:MGI:2384782
    See related
    Ensembl:ENSMUSG00000032519 AllianceGenome:MGI:2384782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    appoptosin
    Summary
    Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in erythrocyte differentiation and glycine import into mitochondrion. Located in mitochondrial inner membrane. Is expressed in cranial ganglion; dorsal root ganglion; liver lobe; and medulla oblongata basal plate. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 24.0), liver E14 (RPKM 21.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a38 in Genome Data Viewer
    Location:
    9 F4; 9 71.4 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119939428..119953570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120110377..120126093)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene predicted gene, 33858 Neighboring gene C-C motif chemokine receptor 8 Neighboring gene STARR-seq mESC enhancer starr_25492 Neighboring gene STARR-positive B cell enhancer ABC_E3867 Neighboring gene STARR-positive B cell enhancer ABC_E2312 Neighboring gene STARR-positive B cell enhancer ABC_E1399 Neighboring gene predicted gene, 24044 Neighboring gene predicted gene, 26448 Neighboring gene ribosomal protein SA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells. Wang T, et al. Mol Med Rep, 2018 May. PMID 29568862, Free PMC Article
    2. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Zhao Y, et al. Neuron, 2015 Sep 2. PMID 26335643, Free PMC Article
    3. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. Zhang H, et al. J Neurosci, 2012 Oct 31. PMID 23115192, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18873

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine import into mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial glycine transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421436.1 → NP_001408365.1  mitochondrial glycine transporter isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110091

    2. NM_144793.2 → NP_659042.1  mitochondrial glycine transporter isoform 1

      See identical proteins and their annotated locations for NP_659042.1

      Status: VALIDATED

      Source sequence(s)
      AC110091, AK078385, BM115906, CJ159224
      Consensus CDS
      CCDS23622.1
      UniProtKB/Swiss-Prot
      Q91XD8
      Related
      ENSMUSP00000035106.6, ENSMUST00000035106.12
      Conserved Domains (2) summary
      PTZ00169
      Location:51 → 318
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:46 → 137
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119939428..119953570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154770.1 → XP_036010663.1  mitochondrial glycine transporter isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:89 → 176
      Mito_carr; Mitochondrial carrier protein

    2. XM_006512021.4 → XP_006512084.1  mitochondrial glycine transporter isoform X4

      See identical proteins and their annotated locations for XP_006512084.1

      Conserved Domains (1) summary
      pfam00153
      Location:89 → 176
      Mito_carr; Mitochondrial carrier protein

    3. XM_030244176.2 → XP_030100036.1  mitochondrial glycine transporter isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:89 → 176
      Mito_carr; Mitochondrial carrier protein

    4. XM_006512019.5 → XP_006512082.1  mitochondrial glycine transporter isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:24 → 115
      Mito_carr; Mitochondrial carrier protein

    5. XM_011242949.3 → XP_011241251.1  mitochondrial glycine transporter isoform X3

      See identical proteins and their annotated locations for XP_011241251.1

      Conserved Domains (1) summary
      pfam00153
      Location:30 → 113
      Mito_carr; Mitochondrial carrier protein

    6. XM_006512020.3 → XP_006512083.1  mitochondrial glycine transporter isoform X3

      See identical proteins and their annotated locations for XP_006512083.1

      Conserved Domains (1) summary
      pfam00153
      Location:30 → 113
      Mito_carr; Mitochondrial carrier protein

    7. XM_011242950.4 → XP_011241252.1  mitochondrial glycine transporter isoform X3

      See identical proteins and their annotated locations for XP_011241252.1

      Conserved Domains (1) summary
      pfam00153
      Location:30 → 113
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XD8.1 GenPept UniProtKB/Swiss-Prot:Q91XD8

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