Akr1b7 aldo-keto reductase family 1, member B7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1b7provided by MGI
Official Full Name: aldo-keto reductase family 1, member B7provided by MGI
Primary source: MGI:MGI:101918
See related: Ensembl:ENSMUSG00000052131 AllianceGenome:MGI:101918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AR; Avdp; MVDP
Summary: Predicted to enable geranylgeranyl reductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to act upstream of or within cellular lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland and genitourinary system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 247.9), adrenal adult (RPKM 164.8) and 1 other tissue See more
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Genomic context

Location:: 6 B1; 6 14.95 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34389297..34400072)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34412362..34423137)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI.
Title: Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI.
ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice.
Title: ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice.
AKR1B7 is expressed within the renin cell throughout development and perturbations to homeostasis, and AKR1B7 is regulated by cAMP levels within the renin cell.
Title: Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.
Data from knockout mice suggest that Akr1b7 has a role in physiological control of white adipose tissue expansion and pathogenesis of obesity.
Title: Depressed levels of prostaglandin F2α in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity.
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Title: Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
protective pathway operative in murine enterohepatic tissues wherein FXR induces AKR1B7 to detoxify bile acids.
Title: AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions
Title: Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.
Akr1b7 is a probable transcriptional target of PXR and CAR, suggesting a novel role for xenobiotic receptors in the detoxification of lipid peroxidation.
Title: The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.
direct target of LXRs throughout the small intestine
Title: Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Triphasic developmental patterns of both AKR1B7 and wild-type transgene expression paralleled changes in SF-1 levels/binding activity; expression was maximal in late embryos, minimal in 6- to 15-d-old neonates, and thereafter progressively restored.
Title: Steroidogenic factor-1 controls the aldose reductase akr1b7 gene promoter in transgenic mice through an atypical binding site.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

D6Mit92.1 (e-PCR), detects polymorphism
- UniSTS:130994

D6Mit92.4 (e-PCR), detects polymorphism
- UniSTS:130995

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables indanol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables prostaglandin H2 endoperoxidase reductase activity	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member B7

Names: aldehyde reductase; aldose reductase-related protein 1; androgen regulated vas deferens protein; vas deferens androgen-dependent protein

NP_033861.2

EC 1.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.