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    Hes3 hes family bHLH transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 15207, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hes3provided by MGI
    Official Full Name
    hes family bHLH transcription factor 3provided by MGI
    Primary source
    MGI:MGI:104877
    See related
    Ensembl:ENSMUSG00000028946 AllianceGenome:MGI:104877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hes-3; bHLHb43
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of timing of neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 9.7) and CNS E11.5 (RPKM 0.6) See more
    Orthologs
    human all
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    Genomic context

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    See Hes3 in Genome Data Viewer
    Location:
    4 E2; 4 83.01 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152369707..152376133, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152285250..152291911, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12198 Neighboring gene predicted gene, 30622 Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene STARR-positive B cell enhancer ABC_E9627 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene ring finger protein 207 Neighboring gene ribosomal protein L22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain. Nikolakopoulou P, et al. Sci Rep, 2018 Jul 27. PMID 30054579, Free PMC Article
    2. Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination. Toutouna L, et al. Brain Res, 2016 Jul 1. PMID 27018293
    3. Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons. Hirata H, et al. J Biol Chem, 2000 Jun 23. PMID 10858455
    4. Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Sharma S, et al. Cancer Res, 2001 Sep 1. PMID 11522634
    5. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Economopoulou M, et al. Int J Radiat Biol, 2014 Aug. PMID 24512568

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hes3 expression is reduced at peak demyelination and is partially restored within 1 week after cuprizone withdrawal. This raises the possibility of Hes3 involvement in demyelination/remyelination.
      Title: Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.
    2. expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium
      Title: Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium.
    3. Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling
      Title: Mamld1 knockdown reduces testosterone production and Cyp17a1 expression in mouse Leydig tumor cells.
    4. CXorf6 transactivates the Hes3 promoter, augments testosterone production
      Title: Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.
    5. inactivation of Hes1 and Hes5, known Notch effectors, and additional inactivation of Hes3 extensively accelerate cell differentiation and cause a wide range of defects in brain formation
      Title: Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144657

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hindbrain morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within oculomotor nerve development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of timing of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within trochlear nerve development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor HES-3
    Names
    hairy and enhancer of split 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403791.1 → NP_001390720.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2

    2. NM_001403792.1 → NP_001390721.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2

    3. NM_001403793.1 → NP_001390722.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2

    4. NM_001403794.1 → NP_001390723.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2

    5. NM_008237.5 → NP_032263.2  transcription factor HES-3

      See identical proteins and their annotated locations for NP_032263.2

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS18997.1
      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2
      UniProtKB/TrEMBL
      Q9JHC5
      Related
      ENSMUSP00000092006.2, ENSMUST00000094438.2
      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152369707..152376133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250192.4 → XP_011248494.1  transcription factor HES-3 isoform X3

      See identical proteins and their annotated locations for XP_011248494.1

      UniProtKB/TrEMBL
      A0A1W2P7Y8, Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:26 → 80
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    2. XM_011250190.4 → XP_011248492.1  transcription factor HES-3 isoform X3

      See identical proteins and their annotated locations for XP_011248492.1

      UniProtKB/TrEMBL
      A0A1W2P7Y8, Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:26 → 80
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    3. XM_011250191.4 → XP_011248493.1  transcription factor HES-3 isoform X3

      See identical proteins and their annotated locations for XP_011248493.1

      UniProtKB/TrEMBL
      A0A1W2P7Y8, Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:26 → 80
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    4. XM_036163689.1 → XP_036019582.1  transcription factor HES-3 isoform X3

      UniProtKB/TrEMBL
      A0A1W2P7Y8, Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:26 → 80
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    5. XM_011250189.3 → XP_011248491.1  transcription factor HES-3 isoform X1

      Conserved Domains (1) summary
      cd18933
      Location:117 → 171
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    6. XM_011250194.4 → XP_011248496.1  transcription factor HES-3 isoform X5

      See identical proteins and their annotated locations for XP_011248496.1

      UniProtKB/TrEMBL
      Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:8 → 62
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    7. XM_036163690.1 → XP_036019583.1  transcription factor HES-3 isoform X3

      UniProtKB/TrEMBL
      A0A1W2P7Y8, Q9JHC5
      Related
      ENSMUSP00000151815.2, ENSMUST00000218045.2
      Conserved Domains (1) summary
      cd18933
      Location:26 → 80
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    8. XM_030253216.1 → XP_030109076.1  transcription factor HES-3 isoform X4

      UniProtKB/Swiss-Prot
      O09083, O09150, Q61657, Q8BTI2
      UniProtKB/TrEMBL
      Q9JHC5
      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61657.2 GenPept UniProtKB/Swiss-Prot:Q61657

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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