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    Adamtsl5 ADAMTS-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 66548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamtsl5provided by MGI
    Official Full Name
    ADAMTS-like 5provided by MGI
    Primary source
    MGI:MGI:1913798
    See related
    Ensembl:ENSMUSG00000043822 AllianceGenome:MGI:1913798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thsd6; 2010109H09Rik
    Summary
    Predicted to enable heparin binding activity and microfibril binding activity. Located in extracellular matrix. Is expressed in several structures, including alimentary system; liver and biliary system; mesothelium; musculoskeletal system; and sensory organ. Orthologous to human ADAMTSL5 (ADAMTS like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 43.1), small intestine adult (RPKM 30.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamtsl5 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80175655..80184246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80339793..80349030, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366 Neighboring gene predicted gene, 51809 Neighboring gene receptor accessory protein 6 Neighboring gene polo like kinase 5 Neighboring gene mex3 RNA binding family member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Bader HL, et al. Matrix Biol, 2012 Sep-Oct. PMID 23010571, Free PMC Article
    2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41037

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microfibril binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 5
    Names
    thrombospondin, type I domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285435.2 → NP_001272364.1  ADAMTS-like protein 5

      See identical proteins and their annotated locations for NP_001272364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC152062
      Consensus CDS
      CCDS48628.1
      UniProtKB/TrEMBL
      D3Z689
      Related
      ENSMUSP00000093097.4, ENSMUST00000095446.10
      Conserved Domains (3) summary
      smart00209
      Location:49 → 98
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:379 → 478
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:207 → 312
      ADAM_spacer1; ADAM-TS Spacer 1

    RNA

    1. NR_104339.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' region and an additional segment in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC152062

    2. NR_104340.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC152062
      Related
      ENSMUST00000124789.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80175655..80184246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243528.2 → XP_011241830.1  ADAMTS-like protein 5 isoform X3

      Conserved Domains (3) summary
      smart00209
      Location:48 → 97
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:378 → 477
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:206 → 311
      ADAM_spacer1; ADAM-TS Spacer 1

    2. XM_011243526.4 → XP_011241828.1  ADAMTS-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011241828.1

      Conserved Domains (3) summary
      smart00209
      Location:112 → 161
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:442 → 541
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:270 → 375
      ADAM_spacer1; ADAM-TS Spacer 1

    3. XM_011243527.2 → XP_011241829.1  ADAMTS-like protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011241829.1

      UniProtKB/TrEMBL
      D3Z689
      Conserved Domains (3) summary
      smart00209
      Location:49 → 98
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:379 → 478
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:207 → 312
      ADAM_spacer1; ADAM-TS Spacer 1

    RNA

    1. XR_001779576.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001113548.1: Suppressed sequence

      Description
      NM_001113548.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_025629.2: Suppressed sequence

      Description
      NM_025629.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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