Adcy8 adenylate cyclase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy8provided by MGI
Official Full Name: adenylate cyclase 8provided by MGI
Primary source: MGI:MGI:1341110
See related: Ensembl:ENSMUSG00000022376 AllianceGenome:MGI:1341110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AC8
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cellular response to glucagon stimulus; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; nephrogenic zone; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 13.1), genital fat pad adult (RPKM 11.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 29.03 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (64570884..64794145, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (64699035..64922296, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication.
Title: Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication.
FXR is a critical transcription factor that mediates ADCY8 expression in pancreatic beta-cells and the chromatin modification associated with Adcy8 transcription.
Title: FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
Title: Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety.
Dysregulation of a survival pathway in adenylyl cyclase 1 and 8 knockout mice was identified following early-life ethanol exposure.
Title: Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder.
Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy
Title: A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.
Title: Multilevel control of glucose homeostasis by adenylyl cyclase 8.
these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.
Title: Functional role of Calcium-stimulated adenylyl cyclase 8 in adaptations to psychological stressors in the mouse: implications for mood disorders.
data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome
Title: Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain.
AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2+-stimulated adenylyl cyclases are required for mossy fiber LTP
Title: Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation.
ACVIII gene is regulated by CREB in vitro and in vivo and this regulation may contribute to CREB-dependent neural plasticity
Title: Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW060868 (e-PCR)
- UniSTS:180765

NoName (e-PCR)
- UniSTS:546632

Adcy8 (e-PCR), detects polymorphism
- UniSTS:546632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled opioid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase A activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucagon stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucagon stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to morphine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to morphine	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glucose mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 8

Names: ATP pyrophosphate-lyase 8; adenylate cyclase type VIII; adenylyl cyclase 8; ca(2+)/calmodulin-activated adenylyl cyclase

NP_001278832.1

EC 4.6.1.1

NP_001318004.1

EC 4.6.1.1

NP_033753.2

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291903.1 → NP_001278832.1 adenylate cyclase type 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AK138244, BC094231

Consensus CDS

CCDS88771.1

UniProtKB/TrEMBL

A0A2I3BQ46, Q3UUN2

Related

ENSMUSP00000154029.2, ENSMUST00000228014.2

Conserved Domains (4) summary

smart00044
Location:364 → 562

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:941 → 1140

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:615 → 709

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:159 → 398

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001331075.1 → NP_001318004.1 adenylate cyclase type 8 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC116996, AC160934, BC094231

UniProtKB/TrEMBL

Q3UUN2
NM_009623.2 → NP_033753.2 adenylate cyclase type 8 isoform 1

See identical proteins and their annotated locations for NP_033753.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK138244, BC094231

Consensus CDS

CCDS27506.1

UniProtKB/Swiss-Prot

G3X8V9, P97490

UniProtKB/TrEMBL

Q3UUN2

Related

ENSMUSP00000023007.6, ENSMUST00000023007.7

Conserved Domains (4) summary

smart00044
Location:364 → 562

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:971 → 1170

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:615 → 709

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:159 → 398

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region