Ino80b INO80 complex subunit B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ino80bprovided by MGI
Official Full Name: INO80 complex subunit Bprovided by MGI
Primary source: MGI:MGI:1917270
See related: Ensembl:ENSMUSG00000030034 AllianceGenome:MGI:1917270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Papa1; Znhit4; HMG1YL4; Hmga1l4; 2510009I23Rik
Summary: Predicted to enable metal ion binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in nuclear body and nucleolus. Predicted to be part of Ino80 complex. Is expressed in Harderian gland; duodenum; metanephros; oviduct; and uterus. Orthologous to human INO80B (INO80 complex subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 45.4), duodenum adult (RPKM 39.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83098746..83102100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83121765..83125119, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the growth-promoting role of IGFBP-2 in prostate cancer is inhibited by its intracellular interaction with PAPA-1.
Title: PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

D6UmiJ27 (e-PCR), detects polymorphism
- UniSTS:260420

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ino80 complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: INO80 complex subunit B

Names: PAP-1 binding protein; PAP-1-associated protein 1; PAPA-1; high mobility group AT-hook 1-like 4; zinc finger HIT domain-containing protein 4; zinc finger, HIT type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023547.2 → NP_076036.2 INO80 complex subunit B

Status: VALIDATED

Source sequence(s)

AC104324

Consensus CDS

CCDS39530.1

UniProtKB/TrEMBL

A0A6Q6QAE5, Q80ZV5

Related

ENSMUSP00000032109.5, ENSMUST00000032109.5

Conserved Domains (2) summary

pfam04795
Location:211 → 289

PAPA-1; PAPA-1-like conserved region

pfam04438
Location:307 → 338

zf-HIT; HIT zinc finger