Ncr1 natural cytotoxicity triggering receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncr1provided by RGD
Official Full Name: natural cytotoxicity triggering receptor 1provided by RGD
Primary source: RGD:621288
See related: EnsemblRapid:ENSRNOG00000027855 AllianceGenome:RGD:621288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ly94; Nkp46; KILR-1; Nk-p46
Summary: Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human NCR1 (natural cytotoxicity triggering receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 75.7), Lung (RPKM 48.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78657409..78665255, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69614744..69622594, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (73178917..73226504, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dendritic cells and hepatoma cell line McA stimulate interferon-gamma production from natural killer (NK) cells in a cell-cell contact-dependent manner via different NK-activating receptors, NKp46 and NKp30, respectively.
Title: Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells.
NKp46 activates natural killer cell cytotoxicity by similar pathways as CD16.
Title: Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of virus	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: natural cytotoxicity triggering receptor 1

Names: NK receptor KILR-1; NK-p46); NKACTR; activating receptor 1; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); natural killer cell p46-related protein; rAR-1; rat-activating receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057199.2 → NP_476547.1 natural cytotoxicity triggering receptor 1 precursor

See identical proteins and their annotated locations for NP_476547.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9Z0H5

UniProtKB/TrEMBL

A0A8L2QED7, A6KNK7

Related

ENSRNOP00000100574.1, ENSRNOT00000155612.1

Conserved Domains (2) summary

smart00410
Location:133 → 195

IG_like; Immunoglobulin like

cl11960
Location:123 → 210

Ig; Immunoglobulin domain