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    Vamp3 vesicle-associated membrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29528, updated on 4-Jan-2025

    Summary

    Official Symbol
    Vamp3provided by RGD
    Official Full Name
    vesicle-associated membrane protein 3provided by RGD
    Primary source
    RGD:61880
    See related
    AllianceGenome:RGD:61880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables syntaxin-1 binding activity. Involved in protein-containing complex assembly. Located in apical plasma membrane; clathrin-coated vesicle membrane; and recycling endosome. Part of SNARE complex. Is active in synaptic vesicle membrane. Orthologous to human VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 355.0), Heart (RPKM 317.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vamp3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166780927..166791522, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161498109..161508704, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168126157..168136628, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487044 Neighboring gene urotensin 2 Neighboring gene period circadian regulator 3 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene uncharacterized LOC134487045 Neighboring gene uncharacterized LOC134487043

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC108618

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNARE binding PubMed 
    enables protein binding PubMed 
    enables syntaxin-1 binding  
    enables syntaxin-1 binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi to plasma membrane protein transport  
    involved_in SNARE complex assembly  
    involved_in SNARE complex assembly  
    acts_upstream_of_or_within calcium-ion regulated exocytosis  
    acts_upstream_of_or_within cellular response to type II interferon  
    acts_upstream_of_or_within establishment of localization in cell  
    NOT involved_in mucus secretion  
    involved_in negative regulation of secretion by cell  
    involved_in negative regulation of secretion by cell  
    NOT involved_in positive regulation of immunoglobulin production  
    involved_in positive regulation of receptor recycling  
    involved_in positive regulation of receptor recycling  
    involved_in protein transport  
    involved_in protein-containing complex assembly PubMed 
    NOT involved_in regulation of histamine secretion by mast cell  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde transport, endosome to Golgi  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in vesicle fusion  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    part_of SNARE complex  
    part_of SNARE complex  
    located_in apical plasma membrane PubMed 
    located_in cell surface  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle membrane PubMed 
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in early endosome  
    located_in early endosome membrane  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular vesicle PubMed 
    located_in neuron projection  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in recycling endosome PubMed 
    located_in recycling endosome  
    located_in recycling endosome membrane  
    located_in secretory granule  
    located_in synapse  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    vesicle-associated membrane protein 3
    Names
    CEB
    VAMP-3
    cellubrevin
    synaptobrevin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057097.2NP_476438.1  vesicle-associated membrane protein 3

      See identical proteins and their annotated locations for NP_476438.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088119
      UniProtKB/Swiss-Prot
      P63025
      UniProtKB/TrEMBL
      A0A8L2QPJ9, A6IUF1
      Conserved Domains (1) summary
      cd15870
      Location:1779
      R-SNARE_VAMP2; SNARE motif of VAMP2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166780927..166791522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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