Styxl1 serine/threonine/tyrosine interacting-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Styxl1provided by RGD
Official Full Name: serine/threonine/tyrosine interacting-like 1provided by RGD
Primary source: RGD:1305845
See related: EnsemblRapid:ENSRNOG00000023366 AllianceGenome:RGD:1305845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dusp24; RGD1305845
Summary: Predicted to enable protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Predicted to be involved in negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of neuron projection development. Predicted to be active in mitochondrion. Orthologous to human STYXL1 (serine/threonine/tyrosine interacting like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 41.2), Adrenal (RPKM 25.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26544059..26576365)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20907410..20940232)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23954563..23987155)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that MK-STYX may be a regulator of RhoA signaling, and implicate this pseudophosphatase as a regulator of neuronal differentiation
Title: The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudophosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine/tyrosine-interacting-like protein 1

Names: map kinase phosphatase-like protein MK-STYX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037788.2 → NP_001032877.2 serine/threonine/tyrosine-interacting-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J0B4, G3V9J5, Q4G076

Related

ENSRNOP00000049678.3, ENSRNOT00000046343.6

Conserved Domains (2) summary

cl00125
Location:33 → 146

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

cl28904
Location:158 → 311

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

26544059..26576365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271486.1 → XP_063127556.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X1

UniProtKB/TrEMBL

A6J0B4, G3V9J5, Q4G076
XM_063271485.1 → XP_063127555.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X1

UniProtKB/TrEMBL

A6J0B4, G3V9J5, Q4G076
XM_006249181.5 → XP_006249243.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006249243.1

UniProtKB/TrEMBL

A6J0B4, G3V9J5, Q4G076

Conserved Domains (2) summary

cl00125
Location:33 → 146

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

cl28904
Location:158 → 311

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063271489.1 → XP_063127559.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X4
XM_063271487.1 → XP_063127557.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X2

UniProtKB/TrEMBL

Q4G076
XM_063271491.1 → XP_063127561.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X5

UniProtKB/TrEMBL

A6J0B5
XM_063271484.1 → XP_063127554.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X1

UniProtKB/TrEMBL

A6J0B4, G3V9J5, Q4G076
XM_063271490.1 → XP_063127560.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X4
XM_063271492.1 → XP_063127562.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X5

UniProtKB/TrEMBL

A6J0B5
XM_063271488.1 → XP_063127558.1 serine/threonine/tyrosine-interacting-like protein 1 isoform X3

UniProtKB/TrEMBL

Q4G076