Neurod6 neuronal differentiation 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurod6provided by RGD
Official Full Name: neuronal differentiation 6provided by RGD
Primary source: RGD:1562793
See related: EnsemblRapid:ENSRNOG00000026055 AllianceGenome:RGD:1562793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562793
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within dentate gyrus development. Predicted to be active in nucleus. Orthologous to human NEUROD6 (neuronal differentiation 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 168.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (86176909..86180155, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84846659..84849905, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85911861..85915107, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response.
Title: The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass.
our findings support the notion that NeuroD6 links neuronal differentiation to survival via the network of molecular chaperones and endows the cells with increased stress tolerance.
Title: NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network.
This study provides first evidence of the underlying mechanism by which the basic helix-loop-helix transcription factor Nex1/Math-2 of the NeuroD-subfamily promotes an active anti-apoptotic program essential to the survival of neurons.
Title: The basic helix-loop-helix transcription factor Nex-1/Math-2 promotes neuronal survival of PC12 cells by modulating the dynamic expression of anti-apoptotic and cell cycle regulators.

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General gene information

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Markers

NEUROD6 (e-PCR)
- UniSTS:503634

Neurod6 (e-PCR), detects polymorphism
- UniSTS:528215

Neurod6 (e-PCR), detects polymorphism
- UniSTS:531344

D44480 (e-PCR)
- UniSTS:179377

BF386980 (e-PCR)
- UniSTS:243902

Neurod6 (e-PCR), detects polymorphism
- UniSTS:507084

PMC57740P1 (e-PCR)
- UniSTS:273364

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenic differentiation factor 6

Names: neurogenic differentiation 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.