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    Rnase1l2 ribonuclease, RNase A family, 1-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnase1l2provided by RGD
    Official Full Name
    ribonuclease, RNase A family, 1-like 2provided by RGD
    Primary source
    RGD:1565230
    See related
    EnsemblRapid:ENSRNOG00000069584 AllianceGenome:RGD:1565230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565230
    Summary
    Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 691.8) and Liver (RPKM 244.6) See more
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    Genomic context

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    See Rnase1l2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26895318..26897025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24421825..24423513)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28127147..28128797)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene epididymal secretory protein E3-beta-like Neighboring gene angiogenin, ribonuclease A family, member 2 Neighboring gene uncharacterized LOC120096963 Neighboring gene ribonuclease A family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pancreatic-type ribonuclease 1 gene duplications in rat species. Dubois JY, et al. J Mol Evol, 2002 Nov. PMID 12399926
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease A activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease pancreatic gamma-type
    Names
    RNase 1 gamma
    pancreatic ribonuclease gamma
    ribonuclease, RNase A family, 1-like 2 (pancreatic)
    NP_001020287.1
    XP_006251937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025116.2 → NP_001020287.1  ribonuclease pancreatic gamma-type precursor

      See identical proteins and their annotated locations for NP_001020287.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q8VD89
      Conserved Domains (1) summary
      smart00092
      Location:29 → 152
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26895318..26897025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251875.3 → XP_006251937.1  ribonuclease pancreatic gamma-type isoform X1

      Related
      ENSRNOP00000072263.3, ENSRNOT00000082938.3
      Conserved Domains (1) summary
      smart00092
      Location:29 → 152
      RNAse_Pc; Pancreatic ribonuclease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD89.1 GenPept UniProtKB/Swiss-Prot:Q8VD89

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