Tent5b terminal nucleotidyltransferase 5B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tent5bprovided by RGD
Official Full Name: terminal nucleotidyltransferase 5Bprovided by RGD
Primary source: RGD:1308967
See related: EnsemblRapid:ENSRNOG00000074445 AllianceGenome:RGD:1308967
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam46b; RGD1308967
Summary: Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Orthologous to human TENT5B (terminal nucleotidyltransferase 5B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 50.9), Lung (RPKM 40.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (150979238..150986548)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (145695358..145702668)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (151692068..151699381)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: terminal nucleotidyltransferase 5B

Names: Protein FAM46B; family with sequence similarity 46, member B; non-canonical poly(A) polymerase FAM46B; putative nucleotidyltransferase FAM46B

NP_001101377.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.