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    Nkain4 Sodium/potassium transporting ATPase interacting 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkain4provided by RGD
    Official Full Name
    Sodium/potassium transporting ATPase interacting 4provided by RGD
    Primary source
    RGD:1305809
    See related
    EnsemblRapid:ENSRNOG00000031834 AllianceGenome:RGD:1305809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305809
    Summary
    Predicted to be involved in regulation of sodium ion transport. Predicted to be located in membrane. Orthologous to human NKAIN4 (sodium/potassium transporting ATPase interacting 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 40.1), Brain (RPKM 26.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nkain4 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188430862..188451561, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168053294..168073944, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176444545..176465197, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein F1 Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene ARF GTPase activating protein 1 Neighboring gene collagen type XX alpha 1 chain Neighboring gene cholinergic receptor nicotinic alpha 4 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Names
    Na+/K+ transporting ATPase interacting 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106550.3 → NP_001100020.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001100020.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM71, D4A8K5
      Related
      ENSRNOP00000042432.3, ENSRNOT00000048807.5
      Conserved Domains (1) summary
      pfam05640
      Location:8 → 133
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_001399301.1 → NP_001386230.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZLZ8, A6KM70
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 206
      NKAIN; Na,K-Atpase Interacting protein

    3. NM_001430355.1 → NP_001417284.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A4Q1

    4. NM_001430356.1 → NP_001417285.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RNA

    1. NR_190889.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188430862..188451561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104692.2 → XP_038960620.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

      Related
      ENSRNOP00000079007.2, ENSRNOT00000106150.2
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 177
      NKAIN; Na,K-Atpase Interacting protein

    2. XM_063283442.1 → XP_063139512.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

    3. XM_008762498.4 → XP_008760720.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

      Related
      ENSRNOP00000075472.2, ENSRNOT00000079283.3
      Conserved Domains (1) summary
      pfam05640
      Location:5 → 172
      NKAIN; Na,K-Atpase Interacting protein

    4. XM_039104693.2 → XP_038960621.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      Conserved Domains (1) summary
      pfam05640
      Location:19 → 160
      NKAIN; Na,K-Atpase Interacting protein

    5. XM_063283441.1 → XP_063139511.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAP3

    6. XM_063283440.1 → XP_063139510.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAP3
    Nucleotide Protein Strain
    Heading Accession and Version

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