Celf2 CUGBP, Elav-like family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Celf2provided by RGD
Official Full Name: CUGBP, Elav-like family member 2provided by RGD
Primary source: RGD:68347
See related: EnsemblRapid:ENSRNOG00000023661 AllianceGenome:RGD:68347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Etr3; Napor; Cugbp2; Brunol3
Summary: Enables mRNA 3'-UTR binding activity. Involved in post-transcriptional gene silencing. Predicted to be located in Flemming body and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 283.6), Spleen (RPKM 168.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (75813928..76639300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (70904462..71729072)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (75259269..75660154)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Cugbp2 regulates splicing and translation of mRNAs linked to sexual differentiation in rats.
Title: Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol.
a regulatory connection between COX-2 and CUGBP2 in the cardiac cells, was demonstrated.
Title: A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules.
NAPOR-3 gene overexpression is necessary for the execution of oxygen glucose deprivation-induced programmed cell death.
Title: NAPOR-3 RNA binding protein is required for apoptosis in hippocampus.
These findings identify a novel paradigm for RNA binding proteins such as CUGBP2 in facilitating opposing functions of mRNA stability and translation inhibition and reveal a mechanism for inhibiting cyclooxygenase-2 expression in cancer cells.
Title: Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain
Title: Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.
tissue-specific distribution of NAPOR, CUG-BP, and other highly related proteins within the nervous system
Title: Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF400671 (e-PCR)
- UniSTS:245016

BE095613 (e-PCR)
- UniSTS:243485

D17Rat180 (e-PCR), detects polymorphism
- UniSTS:226880

BF390310 (e-PCR)
- UniSTS:249437

AU048037 (e-PCR)
- UniSTS:109935

Celf2 (e-PCR), detects polymorphism
- UniSTS:546694

BF388238 (e-PCR)
- UniSTS:244876

RH137713 (e-PCR)
- UniSTS:219800

BF402956 (e-PCR)
- UniSTS:245961

BF390754 (e-PCR)
- UniSTS:249549

AI008532 (e-PCR)
- UniSTS:250587

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splice site recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CUGBP Elav-like family member 2

Names: CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; Cugbp- and Etr3-like factor 2; RNA-binding protein BRUNOL-3; RNA-binding protein Brunol3; bruno-like protein 3; elav-type RNA-binding protein 3; neuroblastoma apoptosis-related RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083586.3 → NP_001077055.2 CUGBP Elav-like family member 2 isoform 2

See identical proteins and their annotated locations for NP_001077055.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5

UniProtKB/TrEMBL

A6JLW4

Related

ENSRNOP00000110458.1, ENSRNOT00000149233.1

Conserved Domains (3) summary

cd12638
Location:434 → 525

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:57 → 140

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:149 → 229

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
NM_017197.4 → NP_058893.2 CUGBP Elav-like family member 2 isoform 1

See identical proteins and their annotated locations for NP_058893.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5

Related

ENSRNOP00000077512.2, ENSRNOT00000106925.2

Conserved Domains (3) summary

cd12638
Location:440 → 531

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:57 → 140

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:149 → 229

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

75813928..76639300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276301.1 → XP_063132371.1 CUGBP Elav-like family member 2 isoform X13
XM_063276302.1 → XP_063132372.1 CUGBP Elav-like family member 2 isoform X15

UniProtKB/TrEMBL

Z4YNP1
XM_063276304.1 → XP_063132374.1 CUGBP Elav-like family member 2 isoform X17

UniProtKB/TrEMBL

Z4YNP1
XM_063276305.1 → XP_063132375.1 CUGBP Elav-like family member 2 isoform X17

UniProtKB/TrEMBL

Z4YNP1
XM_063276307.1 → XP_063132377.1 CUGBP Elav-like family member 2 isoform X20

UniProtKB/TrEMBL

Z4YNP1
XM_063276308.1 → XP_063132378.1 CUGBP Elav-like family member 2 isoform X20

UniProtKB/TrEMBL

Z4YNP1
XM_063276290.1 → XP_063132360.1 CUGBP Elav-like family member 2 isoform X1
XM_063276289.1 → XP_063132359.1 CUGBP Elav-like family member 2 isoform X1
XM_063276292.1 → XP_063132362.1 CUGBP Elav-like family member 2 isoform X3

UniProtKB/TrEMBL

Z4YNP1
XM_039095585.2 → XP_038951513.2 CUGBP Elav-like family member 2 isoform X6
XM_063276293.1 → XP_063132363.1 CUGBP Elav-like family member 2 isoform X4

UniProtKB/TrEMBL

Z4YNP1
XM_063276294.1 → XP_063132364.1 CUGBP Elav-like family member 2 isoform X4

UniProtKB/TrEMBL

Z4YNP1
XM_063276291.1 → XP_063132361.1 CUGBP Elav-like family member 2 isoform X2

UniProtKB/TrEMBL

Z4YNP1

Related

ENSRNOP00000093103.1, ENSRNOT00000113911.2
XM_063276295.1 → XP_063132365.1 CUGBP Elav-like family member 2 isoform X5

UniProtKB/TrEMBL

Z4YNP1
XM_063276296.1 → XP_063132366.1 CUGBP Elav-like family member 2 isoform X5

UniProtKB/TrEMBL

Z4YNP1
XM_063276297.1 → XP_063132367.1 CUGBP Elav-like family member 2 isoform X5

UniProtKB/TrEMBL

Z4YNP1

Related

ENSRNOP00000104906.1, ENSRNOT00000162110.1
XM_063276298.1 → XP_063132368.1 CUGBP Elav-like family member 2 isoform X7
XM_008771863.4 → XP_008770085.2 CUGBP Elav-like family member 2 isoform X10

UniProtKB/TrEMBL

Z4YNP1
XM_063276299.1 → XP_063132369.1 CUGBP Elav-like family member 2 isoform X8

UniProtKB/TrEMBL

Z4YNP1
XM_063276300.1 → XP_063132370.1 CUGBP Elav-like family member 2 isoform X12

UniProtKB/TrEMBL

A0A8I5ZWV8, Z4YNP1

Related

ENSRNOP00000083368.1, ENSRNOT00000097332.2
XM_039095591.2 → XP_038951519.1 CUGBP Elav-like family member 2 isoform X19

Conserved Domains (3) summary

cd12638
Location:438 → 529

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:51 → 134

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:143 → 223

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063276310.1 → XP_063132380.1 CUGBP Elav-like family member 2 isoform X22

UniProtKB/TrEMBL

A0A8I6G2N0, Z4YNP1
XM_063276311.1 → XP_063132381.1 CUGBP Elav-like family member 2 isoform X22

UniProtKB/TrEMBL

A0A8I6G2N0, Z4YNP1

Related

ENSRNOP00000095071.2, ENSRNOT00000093949.2
XM_063276309.1 → XP_063132379.1 CUGBP Elav-like family member 2 isoform X21

UniProtKB/TrEMBL

Z4YNP1
XM_063276314.1 → XP_063132384.1 CUGBP Elav-like family member 2 isoform X24

UniProtKB/TrEMBL

Z4YNP1
XM_063276315.1 → XP_063132385.1 CUGBP Elav-like family member 2 isoform X24

UniProtKB/TrEMBL

Z4YNP1

Related

ENSRNOP00000078975.2, ENSRNOT00000113172.2
XM_063276324.1 → XP_063132394.1 CUGBP Elav-like family member 2 isoform X33

UniProtKB/TrEMBL

A0A8I6GLG1, Z4YNP1
XM_063276318.1 → XP_063132388.1 CUGBP Elav-like family member 2 isoform X26

UniProtKB/TrEMBL

Z4YNP1
XM_063276306.1 → XP_063132376.1 CUGBP Elav-like family member 2 isoform X18

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5
XM_063276322.1 → XP_063132392.1 CUGBP Elav-like family member 2 isoform X30

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5
XM_063276303.1 → XP_063132373.1 CUGBP Elav-like family member 2 isoform X16

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5
XM_063276321.1 → XP_063132391.1 CUGBP Elav-like family member 2 isoform X29

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5
XM_063276327.1 → XP_063132397.1 CUGBP Elav-like family member 2 isoform X29

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5
XM_063276320.1 → XP_063132390.1 CUGBP Elav-like family member 2 isoform X28

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5

UniProtKB/TrEMBL

A6JLW4
XM_039095604.2 → XP_038951532.1 CUGBP Elav-like family member 2 isoform X31

UniProtKB/Swiss-Prot

A1L1J5, O88756, Q78ZF0, Q792H5

UniProtKB/TrEMBL

A0A8I5ZJI1

Related

ENSRNOP00000084524.2, ENSRNOT00000101298.2

Conserved Domains (4) summary

TIGR01661
Location:60 → 473

ELAV_HUD_SF; ELAV/HuD family splicing factor

cd12631
Location:57 → 140

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:149 → 229

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cl17169
Location:437 → 477

RRM_SF; RNA recognition motif (RRM) superfamily
XM_039095586.2 → XP_038951514.1 CUGBP Elav-like family member 2 isoform X9

Conserved Domains (3) summary

cd12638
Location:454 → 545

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:67 → 150

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:159 → 239

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_008771862.4 → XP_008770084.2 CUGBP Elav-like family member 2 isoform X11

UniProtKB/TrEMBL

Z4YNP1

Related

ENSRNOP00000023436.6, ENSRNOT00000023436.6
XM_039095584.2 → XP_038951512.2 CUGBP Elav-like family member 2 isoform X14

UniProtKB/TrEMBL

Z4YNP1
XM_008771864.4 → XP_008770086.2 CUGBP Elav-like family member 2 isoform X14

UniProtKB/TrEMBL

Z4YNP1
XM_063276316.1 → XP_063132386.1 CUGBP Elav-like family member 2 isoform X25

UniProtKB/TrEMBL

Z4YNP1
XM_063276317.1 → XP_063132387.1 CUGBP Elav-like family member 2 isoform X25

UniProtKB/TrEMBL

Z4YNP1

Related

ENSRNOP00000084295.2, ENSRNOT00000095889.2
XM_063276325.1 → XP_063132395.1 CUGBP Elav-like family member 2 isoform X34

UniProtKB/TrEMBL

Z4YNP1
XM_039095594.2 → XP_038951522.1 CUGBP Elav-like family member 2 isoform X23

UniProtKB/TrEMBL

A0A8I5ZWW9, Z4YNP1

Conserved Domains (3) summary

cd12638
Location:429 → 520

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:46 → 129

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:138 → 218

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063276313.1 → XP_063132383.1 CUGBP Elav-like family member 2 isoform X23

UniProtKB/TrEMBL

A0A8I5ZWW9, Z4YNP1
XM_063276323.1 → XP_063132393.1 CUGBP Elav-like family member 2 isoform X32

UniProtKB/TrEMBL

Z4YNP1
XM_039095595.2 → XP_038951523.1 CUGBP Elav-like family member 2 isoform X27

UniProtKB/TrEMBL

Z4YNP1

Conserved Domains (3) summary

cd12638
Location:423 → 514

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:46 → 129

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:138 → 218

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063276319.1 → XP_063132389.1 CUGBP Elav-like family member 2 isoform X27

UniProtKB/TrEMBL

Z4YNP1
XM_063276326.1 → XP_063132396.1 CUGBP Elav-like family member 2 isoform X35

UniProtKB/TrEMBL

Z4YNP1