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    Gstm1 glutathione S-transferase mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24423, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gstm1provided by RGD
    Official Full Name
    glutathione S-transferase mu 1provided by RGD
    Primary source
    RGD:2755
    See related
    EnsemblRapid:ENSRNOG00000029726 AllianceGenome:RGD:2755
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTA3
    Summary
    Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1582.2), Testes (RPKM 556.6) and 7 other tissues See more
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    Genomic context

    See Gstm1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198338005..198346007, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195649845..195655402, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210803869..210809461, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 3 Neighboring gene glutathione S-transferase mu 2 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene glutathione S-transferase mu 4 Neighboring gene small nucleolar RNA SNORD47

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding  
    enables glutathione binding PubMed 
    enables glutathione binding  
    enables glutathione transferase activity  
    enables glutathione transferase activity PubMed 
    enables glutathione transferase activity  
    enables glutathione transferase activity  
    enables identical protein binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables nickel cation binding PubMed 
    enables protein homodimerization activity  
    enables protein kinase binding PubMed 
    enables steroid binding PubMed 
    Process Evidence Code Pubs
    involved_in cellular detoxification of nitrogen compound  
    acts_upstream_of_or_within cellular response to xenobiotic stimulus  
    involved_in glutathione derivative biosynthetic process  
    involved_in glutathione derivative biosynthetic process  
    involved_in glutathione metabolic process  
    involved_in glutathione metabolic process PubMed 
    involved_in glutathione metabolic process PubMed 
    involved_in glutathione metabolic process  
    involved_in hepoxilin biosynthetic process  
    involved_in hepoxilin biosynthetic process  
    involved_in nitrobenzene metabolic process  
    involved_in prostaglandin metabolic process  
    involved_in prostaglandin metabolic process  
    involved_in response to amino acid PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to metal ion PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sensory perception of smell  
    involved_in xenobiotic catabolic process PubMed 
    involved_in xenobiotic catabolic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in extracellular region PubMed 
    located_in intercellular bridge  
    located_in mitochondrion  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase Mu 1
    Names
    GST 3-3
    GST Yb1
    GSTM1-1
    glutathione S-transferase M1
    glutathione S-transferase Yb-1 subunit
    glutathione-S-transferase, mu type 1 (Yb1)
    NP_058710.2
    XP_038957642.1
    XP_063137360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017014.2NP_058710.2  glutathione S-transferase Mu 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P04905
      UniProtKB/TrEMBL
      A6HUX0, G3V983
      Related
      ENSRNOP00000039050.3, ENSRNOT00000047139.5
      Conserved Domains (2) summary
      cd03209
      Location:92211
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198338005..198346007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101714.2XP_038957642.1  glutathione S-transferase Mu 1 isoform X1

      Conserved Domains (2) summary
      cd03209
      Location:43162
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:337
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. XM_063281290.1XP_063137360.1  glutathione S-transferase Mu 1 isoform X2

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