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    Lamp3 lysosomal-associated membrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lamp3provided by RGD
    Official Full Name
    lysosomal-associated membrane protein 3provided by RGD
    Primary source
    RGD:1307928
    See related
    EnsemblRapid:ENSRNOG00000022792 AllianceGenome:RGD:1307928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including negative regulation of proteolysis; regulation of autophagy; and response to interferon-alpha. Located in alveolar lamellar body membrane. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 799.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lamp3 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94657817..94726451)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (81153491..81224643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84930965..85000694)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095700 Neighboring gene microRNA 6323 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Neighboring gene olfactory receptor family 2 subfamily AJ member 4B Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Plasma membrane trafficking in alveolar type II cells. Albrecht S, et al. Cell Physiol Biochem, 2010. PMID 20054147
    2. Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer. Mine KL, et al. Nat Commun, 2013. PMID 23651994, Free PMC Article
    3. Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells. Zhou Z, et al. Virol J, 2011 Aug 3. PMID 21810281, Free PMC Article
    4. Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Salaun B, et al. Eur J Immunol, 2003 Sep. PMID 12938238
    5. Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. Dominguez-Bautista JA, et al. Eur J Cell Biol, 2015 Mar-Apr. PMID 25681212

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in alveolar lamellar body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in alveolar lamellar body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosome-associated membrane glycoprotein 3
    Names
    LAMP-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012015.1 → NP_001012015.1  lysosome-associated membrane glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_001012015.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083787
      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6
      Related
      ENSRNOP00000087228.1, ENSRNOT00000108731.2
      Conserved Domains (1) summary
      pfam01299
      Location:216 → 358
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      94657817..94726451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270465.1 → XP_063126535.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    2. XM_063270467.1 → XP_063126537.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    3. XM_039088271.2 → XP_038944199.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6
      Related
      ENSRNOP00000038456.3, ENSRNOT00000034498.7
      Conserved Domains (1) summary
      pfam01299
      Location:216 → 358
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    4. XM_063270462.1 → XP_063126532.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    5. XM_063270463.1 → XP_063126533.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    6. XM_063270464.1 → XP_063126534.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    7. XM_063270466.1 → XP_063126536.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    8. XM_039088272.2 → XP_038944200.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6
      Conserved Domains (1) summary
      pfam01299
      Location:216 → 358
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    9. XM_063270468.1 → XP_063126538.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6

    10. XM_039088273.2 → XP_038944201.1  lysosome-associated membrane glycoprotein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5XI99
      UniProtKB/TrEMBL
      A0A8I6A5E6
      Conserved Domains (1) summary
      pfam01299
      Location:216 → 358
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI99.1 GenPept UniProtKB/Swiss-Prot:Q5XI99

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