Ddi2 DNA damage inducible 1 homolog 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddi2provided by RGD
Official Full Name: DNA damage inducible 1 homolog 2provided by RGD
Primary source: RGD:1311815
See related: EnsemblRapid:ENSRNOG00000012274 AllianceGenome:RGD:1311815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311815
Summary: Predicted to enable aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 307.6), Kidney (RPKM 214.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (159272625..159318365, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153989591..154035342, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (160230958..160282836, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein DDI1 homolog 2

Names: DNA-damage inducible protein 2

NP_001382515.1

EC 3.4.23.-

XP_006239367.1

EC 3.4.23.-

XP_006239368.1

EC 3.4.23.-

XP_006239370.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395586.1 → NP_001382515.1 protein DDI1 homolog 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8J8Y1M0

Conserved Domains (2) summary

cd05479
Location:221 → 343

RP_DDI; retropepsin-like domain of DNA damage inducible protein

cd01796
Location:1 → 76

Ubl_Ddi1_like; ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

159272625..159318365 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239305.5 → XP_006239367.1 protein DDI1 homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0Y2, A0A8I6GFW9

Related

ENSRNOP00000077256.1, ENSRNOT00000119479.2

Conserved Domains (4) summary

cd05479
Location:221 → 343

RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein

cd01796
Location:3 → 76

DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain

smart00213
Location:1 → 74

UBQ; Ubiquitin homologues

pfam09786
Location:387 → 535

CytochromB561_N; Cytochrome B561, N terminal
XM_006239306.5 → XP_006239368.1 protein DDI1 homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GFW9

Related

ENSRNOP00000087348.1, ENSRNOT00000109253.2

Conserved Domains (3) summary

cd05479
Location:218 → 340

RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein

pfam09786
Location:384 → 532

CytochromB561_N; Cytochrome B561, N terminal

cl00155
Location:43 → 73

UBQ; Ubiquitin-like proteins
XM_006239308.5 → XP_006239370.1 protein DDI1 homolog 2 isoform X3

UniProtKB/TrEMBL

A6ITV4

Related

ENSRNOP00000016352.8, ENSRNOT00000016352.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001034149.1: Suppressed sequence

Description

NM_001034149.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.