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    Brwd1 bromodomain and WD repeat domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304061, updated on 9-Dec-2024

    Summary

    Symbol
    Brwd1provided by RGD
    Full Name
    bromodomain and WD repeat domain containing 1provided by RGD
    Primary source
    RGD:1309030
    See related
    EnsemblRapid:ENSRNOG00000001632 AllianceGenome:RGD:1309030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr9
    Summary
    Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including axoneme; motile cilium; and nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human BRWD1 (bromodomain and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 136.5), Kidney (RPKM 134.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Brwd1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48756174..48853692, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35286364..35378768, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36338080..36430473, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352314 Neighboring gene proteasome assembly chaperone 1 Neighboring gene microRNA 6324 Neighboring gene large ribosomal subunit protein eL43-like Neighboring gene high mobility group nucleosome binding domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoskeleton organization  
    involved_in cytoskeleton organization  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in axoneme  
    located_in cytosol  
    located_in cytosol  
    located_in motile cilium  
    located_in nucleolus  
    located_in nucleolus  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    bromodomain and WD repeat-containing protein 1
    Names
    WD repeat domain 9
    bromodomain and WD repeat-containing protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371922.2NP_001358851.1  bromodomain and WD repeat-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I5XUX5, D4AAI9
      Related
      ENSRNOP00000076448.1, ENSRNOT00000108092.2
      Conserved Domains (4) summary
      cd05496
      Location:13161432
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48756174..48853692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248186.5XP_006248248.1  bromodomain and WD repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      D4AAI9
      Related
      ENSRNOP00000111509.1, ENSRNOT00000155372.1
      Conserved Domains (6) summary
      cd05496
      Location:13161432
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam09507
      Location:16971999
      CDC27; DNA polymerase subunit Cdc27
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    2. XM_039088408.2XP_038944336.1  bromodomain and WD repeat-containing protein 1 isoform X2

      Conserved Domains (4) summary
      cd05496
      Location:13161432
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    3. XM_039088409.2XP_038944337.1  bromodomain and WD repeat-containing protein 1 isoform X3

      Conserved Domains (4) summary
      cd05496
      Location:13161432
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]

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