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    Arhgap32 Rho GTPase activating protein 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap32provided by RGD
    Official Full Name
    Rho GTPase activating protein 32provided by RGD
    Primary source
    RGD:1305267
    See related
    EnsemblRapid:ENSRNOG00000008709 AllianceGenome:RGD:1305267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Grit; Rics; p250GAP
    Summary
    Predicted to enable GTPase activator activity. Involved in cerebellum development; positive regulation of axon extension; and positive regulation of neuron migration. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ARHGAP32 (Rho GTPase activating protein 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 113.0), Adrenal (RPKM 69.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap32 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38679368..38939960)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30421269..30681653)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33131874..33392198)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 7 Neighboring gene ribosomal protein S19 like 2 Neighboring gene lactate dehydrogenase A like 1 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like Neighboring gene uncharacterized LOC134480155 Neighboring gene ribosomal protein L35 like 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myo9b and RICS modulate dendritic morphology of cortical neurons. Long H, et al. Cereb Cortex, 2013 Jan. PMID 22250289
    2. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. Kannan M, et al. PLoS One, 2012. PMID 23226367, Free PMC Article
    3. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. Moon SY, et al. J Biol Chem, 2003 Feb 7. PMID 12454018
    4. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
    5. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. Okabe T, et al. J Biol Chem, 2003 Mar 14. PMID 12531901

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data demonstrate that Myo9b and RICS repress RhoA/Rock signaling and modulate dendritic morphogenesis in cortical neurons
      Title: Myo9b and RICS modulate dendritic morphology of cortical neurons.
    2. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases
      Title: RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
    3. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases.
      Title: RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427098.1 → NP_001414027.1  rho GTPase-activating protein 32

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GFW8, A0A8I6GIC6
      Related
      ENSRNOP00000099101.1, ENSRNOT00000173150.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      38679368..38939960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265405.1 → XP_063121475.1  rho GTPase-activating protein 32 isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y6H2, A0A8I6GFW8

    2. XM_017595999.3 → XP_017451488.1  rho GTPase-activating protein 32 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GFW8, A0A8I6GIC6
      Conserved Domains (3) summary
      cd07298
      Location:101 → 215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237 → 290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342 → 536
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

    3. XM_063265400.1 → XP_063121470.1  rho GTPase-activating protein 32 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GFW8
      Related
      ENSRNOP00000112297.1, ENSRNOT00000170083.1

    4. XM_063265401.1 → XP_063121471.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GFW8
      Related
      ENSRNOP00000089744.2, ENSRNOT00000099034.2

    5. XM_017595997.3 → XP_017451486.3  rho GTPase-activating protein 32 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GFW8

    6. XM_063265404.1 → XP_063121474.1  rho GTPase-activating protein 32 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GFW8

    7. XM_063265406.1 → XP_063121476.1  rho GTPase-activating protein 32 isoform X12

    8. XM_063265402.1 → XP_063121472.1  rho GTPase-activating protein 32 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GFW8, F1MAK3
      Related
      ENSRNOP00000088168.2, ENSRNOT00000119263.2

    9. XM_017595996.3 → XP_017451485.1  rho GTPase-activating protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GFW8

    10. XM_008766074.4 → XP_008764296.1  rho GTPase-activating protein 32 isoform X7

      See identical proteins and their annotated locations for XP_008764296.1

      UniProtKB/TrEMBL
      A0A8I6GFW8
      Conserved Domains (3) summary
      cd07298
      Location:127 → 241
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:263 → 316
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:368 → 562
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    11. XM_006242777.5 → XP_006242839.1  rho GTPase-activating protein 32 isoform X10

      See identical proteins and their annotated locations for XP_006242839.1

      UniProtKB/TrEMBL
      A0A8I6GFW8
      Conserved Domains (3) summary
      cd11835
      Location:50 → 103
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:155 → 349
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:1 → 28
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    12. XM_039082294.2 → XP_038938222.1  rho GTPase-activating protein 32 isoform X11

      UniProtKB/TrEMBL
      B5DEI5
      Related
      ENSRNOP00000011589.6, ENSRNOT00000011589.8
      Conserved Domains (1) summary
      cd04384
      Location:19 → 213
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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