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    Mrpl39 mitochondrial ribosomal protein L39 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl39provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L39provided by RGD
    Primary source
    RGD:1591507
    See related
    EnsemblRapid:ENSRNOG00000047563 AllianceGenome:RGD:1591507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleotide binding activity. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 162.8), Thymus (RPKM 141.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl39 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37266116..37281612, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23779655..23795146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24181605..24200022, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126A, pseudogene 3 Neighboring gene Mir155 host gene Neighboring gene microRNA 155 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene junctional adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL39
    Names
    39S ribosomal protein L39, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398882.1 → NP_001385811.1  large ribosomal subunit protein mL39

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6A9P7, A6JL56, M0R6J0
      Related
      ENSRNOP00000065042.3, ENSRNOT00000074032.4
      Conserved Domains (1) summary
      PLN02908
      Location:27 → 270
      PLN02908; threonyl-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37266116..37281612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088767.2 → XP_038944695.1  large ribosomal subunit protein mL39 isoform X1

      Conserved Domains (2) summary
      PLN02908
      Location:27 → 155
      PLN02908; threonyl-tRNA synthetase
      cd01616
      Location:63 → 125
      TGS; TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold

    2. XM_063270766.1 → XP_063126836.1  large ribosomal subunit protein mL39 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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