Tgfb1i1 transforming growth factor beta 1 induced transcript 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgfb1i1provided by RGD
Official Full Name: transforming growth factor beta 1 induced transcript 1provided by RGD
Primary source: RGD:620173
See related: EnsemblRapid:ENSRNOG00000019965 AllianceGenome:RGD:620173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ara55; Hic-5
Summary: Enables I-SMAD binding activity. Predicted to be involved in positive regulation of epithelial to mesenchymal transition; positive regulation of macromolecule metabolic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell differentiation; morphogenesis of embryonic epithelium; and negative regulation of fat cell differentiation. Predicted to be located in cytosol; focal adhesion; and intracellular membrane-bounded organelle. Orthologous to human TGFB1I1 (transforming growth factor beta 1 induced transcript 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 49.5), Lung (RPKM 48.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192258992..192265903)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182828553..182835465)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199664039..199670970)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.
Title: Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.
the reciprocal regulation of MRTF-A localization by Hic-5 and Hic-5 expression by MRTF-A, plays a crucial role in myofibroblast differentiation in response to TGF-beta.
Title: Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation.
data indicate that there is a prosclerotic feedback loop in mesangial cells dependent on matrix-derived signals in which Hic-5 is a pivotal signaling protein. This feedback loop is TGF-beta-independent
Title: Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β.
Hypothesized that reducing collagen I accumulation in glomerulosclerosis would lower Hic-5 expression,reducing apoptosis, and maintain glomerular integrity. NTU281 treatment reduced glomerular col I accumulation, Hic-5 and alpha-SMA expression, and apoptosis.
Title: Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy.
these results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway.
Title: Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8.
These findings demonstrate a novel role for hic-5 in the regulation of actin cytoskeleton and fetal gene expression.
Title: Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes.
the association of Hsp27 and Hic-5 are required for the reorganization of the actin cytoskeleton and force development in small arteries
Title: Regulation of contractility by Hsp27 and Hic-5 in rat mesenteric small arteries.
the C terminus of ARA55 is critical for suppression of Smad3 activity
Title: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.
Hic-5 mRNA & protein expression on various days of pregnancy in circular & longitudinal myometrial muscles was measured. It may play a role in focal adhesion remodeling in the rat myometrium during late pregnancy.
Title: The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables Roundabout binding	IEA Inferred from Electronic Annotation more info
enables Roundabout binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of embryonic epithelium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming growth factor beta-1-induced transcript 1 protein

Names: androgen receptor-associated protein of 55 kDa; hydrogen peroxide-inducible clone 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191840.1 → NP_001178769.1 transforming growth factor beta-1-induced transcript 1 protein

See identical proteins and their annotated locations for NP_001178769.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q99PD6

UniProtKB/TrEMBL

A6I9Z1, A6I9Z2

Related

ENSRNOP00000078945.2, ENSRNOT00000115598.2

Conserved Domains (5) summary

cd09337
Location:287 → 338

LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family

cd09409
Location:346 → 398

LIM3_Paxillin; The third LIM domain of paxillin

cd09412
Location:405 → 456

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cd09336
Location:228 → 280

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:57 → 106

Paxillin; Paxillin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

192258992..192265903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230350.5 → XP_006230412.1 transforming growth factor beta-1-induced transcript 1 protein isoform X2

See identical proteins and their annotated locations for XP_006230412.1

UniProtKB/TrEMBL

A0A8L2QR72

Conserved Domains (5) summary

cd09337
Location:248 → 299

LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family

cd09412
Location:366 → 417

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cd09336
Location:189 → 241

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:27 → 67

Paxillin; Paxillin family

cl02475
Location:307 → 359

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_017589800.3 → XP_017445289.1 transforming growth factor beta-1-induced transcript 1 protein isoform X3

UniProtKB/TrEMBL

A0A8L2QR72, A6I9Z3

Conserved Domains (3) summary

cd09337
Location:176 → 227

LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family

cd09412
Location:294 → 345

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cl02475
Location:117 → 169

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_063275859.1 → XP_063131929.1 transforming growth factor beta-1-induced transcript 1 protein isoform X3

UniProtKB/TrEMBL

A0A8L2QR72, A6I9Z3
XM_063275861.1 → XP_063131931.1 transforming growth factor beta-1-induced transcript 1 protein isoform X4
XM_039092864.2 → XP_038948792.1 transforming growth factor beta-1-induced transcript 1 protein isoform X2

UniProtKB/TrEMBL

A0A8L2QR72

Conserved Domains (5) summary

cd09337
Location:248 → 299

LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family

cd09412
Location:366 → 417

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cd09336
Location:189 → 241

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:27 → 67

Paxillin; Paxillin family

cl02475
Location:307 → 359

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006230349.4 → XP_006230411.1 transforming growth factor beta-1-induced transcript 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZLR8, A6I9Z2

Related

ENSRNOP00000082835.2, ENSRNOT00000097108.2

Conserved Domains (5) summary

cd09337
Location:299 → 350

LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family

cd09409
Location:358 → 410

LIM3_Paxillin; The third LIM domain of paxillin

cd09412
Location:417 → 468

LIM4_Leupaxin; The fourth LIM domain of Leupaxin

cd09336
Location:240 → 292

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:69 → 118

Paxillin; Paxillin family