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    Htr2c 5-hydroxytryptamine receptor 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25187, updated on 9-Dec-2024

    Summary

    Official Symbol
    Htr2cprovided by RGD
    Official Full Name
    5-hydroxytryptamine receptor 2Cprovided by RGD
    Primary source
    RGD:2848
    See related
    EnsemblRapid:ENSRNOG00000030877 AllianceGenome:RGD:2848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5-HT2C; 5HT-1C; 5-HTR2C
    Summary
    Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward (RPKM 157.0) See more
    Orthologs
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    Genomic context

    See Htr2c in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (115453190..115682325)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (110640777..110870288)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (118084520..118318040)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 1752 Neighboring gene peptidylprolyl isomerase D, pseudogene 20 Neighboring gene small nucleolar RNA, H/ACA box 35 Neighboring gene microRNA 3552 Neighboring gene microRNA 1912 Neighboring gene microRNA 764 Neighboring gene microRNA 1298 Neighboring gene microRNA 448 Neighboring gene nuclear receptor subfamily 5, group A, member 2, pseudogene 1 Neighboring gene interleukin 13 receptor subunit alpha 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
    enables G protein-coupled serotonin receptor activity  
    enables G protein-coupled serotonin receptor activity  
    enables G protein-coupled serotonin receptor activity PubMed 
    enables G protein-coupled serotonin receptor activity  
    enables Gq/11-coupled serotonin receptor activity  
    enables Gq/11-coupled serotonin receptor activity  
    enables identical protein binding  
    enables neurotransmitter receptor activity  
    enables protein binding PubMed 
    enables serotonin binding  
    enables serotonin receptor activity  
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger PubMed 
    involved_in G protein-coupled serotonin receptor signaling pathway  
    involved_in G protein-coupled serotonin receptor signaling pathway  
    involved_in animal organ regeneration PubMed 
    involved_in behavioral fear response  
    involved_in behavioral fear response  
    involved_in behavioral response to nicotine PubMed 
    involved_in cGMP-mediated signaling  
    involved_in chemical synaptic transmission  
    involved_in feeding behavior  
    involved_in feeding behavior PubMed 
    involved_in feeding behavior  
    involved_in intracellular calcium ion homeostasis  
    involved_in locomotory behavior  
    involved_in negative regulation of dopamine metabolic process PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating serotonin receptor signaling pathway  
    involved_in phospholipase C-activating serotonin receptor signaling pathway PubMed 
    involved_in phospholipase C-activating serotonin receptor signaling pathway  
    involved_in phospholipase D-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of acetylcholine secretion, neurotransmission PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling  
    acts_upstream_of_or_within positive regulation of fat cell differentiation  
    involved_in positive regulation of gamma-aminobutyric acid secretion PubMed 
    involved_in positive regulation of phosphatidylinositol biosynthetic process  
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in regulation of appetite  
    involved_in regulation of appetite  
    involved_in regulation of corticotropin-releasing hormone secretion  
    involved_in regulation of corticotropin-releasing hormone secretion  
    involved_in regulation of nervous system process  
    involved_in regulation of nervous system process  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sensitization PubMed 
    involved_in serotonin receptor signaling pathway  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    part_of G protein-coupled serotonin receptor complex  
    located_in cell surface PubMed 
    is_active_in dendrite  
    located_in external side of plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in synapse  

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 2C
    Names
    5-HT-1C
    5-HT1C
    5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    5-hydroxytryptamine receptor 1C
    serotonin 1c receptor
    serotonin receptor 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012765.3NP_036897.2  5-hydroxytryptamine receptor 2C precursor

      See identical proteins and their annotated locations for NP_036897.2

      Status: REVIEWED

      Source sequence(s)
      BF285550, BF409467, BF415855, CB557712, CB613191, CB784937, JAXUCZ010000021, U35315
      UniProtKB/Swiss-Prot
      P08909
      UniProtKB/TrEMBL
      F1LPS1
      Related
      ENSRNOP00000060345.3, ENSRNOT00000065293.4
      Conserved Domains (2) summary
      pfam00001
      Location:71370
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:64248
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      115453190..115682325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099497.2XP_038955425.2  5-hydroxytryptamine receptor 2C isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY06
    2. XM_063279820.1XP_063135890.1  5-hydroxytryptamine receptor 2C isoform X1

      UniProtKB/TrEMBL
      A6KGA9, Q62842
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