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    Wfdc1 WAP four-disulfide core domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171112, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wfdc1provided by RGD
    Official Full Name
    WAP four-disulfide core domain 1provided by RGD
    Primary source
    RGD:68938
    See related
    EnsemblRapid:ENSRNOG00000015904 AllianceGenome:RGD:68938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ps20
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of epithelial cell proliferation; regulation of cell growth; and response to estradiol. Located in extracellular space. Orthologous to human WFDC1 (WAP four-disulfide core domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 380.7), Lung (RPKM 370.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wfdc1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64628689..64647739)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47720191..47739121)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52313771..52332721)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene adenosine deaminase domain containing 2 Neighboring gene potassium voltage-gated channel modifier subfamily G member 4 Neighboring gene transfer RNA alanine (anticodon AGC) 94 Neighboring gene ATPase secretory pathway Ca2+ transporting 2 Neighboring gene uncharacterized LOC102549202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens. Hung H. Endocrinology, 2005 May. PMID 15677758
    2. Decreased stromal expression and increased epithelial expression of WFDC1/ps20 in prostate cancer is associated with reduced recurrence-free survival. McAlhany SJ, et al. Prostate, 2004 Oct 1. PMID 15305341
    3. Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. Larsen M, et al. J Biol Chem, 1998 Feb 20. PMID 9468514
    4. Purification of a novel protein (ps20) from urogenital sinus mesenchymal cells with growth inhibitory properties in vitro. Rowley DR, et al. J Biol Chem, 1995 Sep 15. PMID 7665628
    5. WFDC1 is a key modulator of inflammatory and wound repair responses. Ressler SJ, et al. Am J Pathol, 2014 Nov. PMID 25219356, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 1
    Names
    20-kDa prostate stromal protein
    prostate stromal protein ps20
    ps20 growth inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133581.2 → NP_598265.1  WAP four-disulfide core domain protein 1 precursor

      See identical proteins and their annotated locations for NP_598265.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      O70280
      UniProtKB/TrEMBL
      A6IZK1
      Related
      ENSRNOP00000021630.3, ENSRNOT00000021630.6
      Conserved Domains (1) summary
      pfam00095
      Location:70 → 98
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64628689..64647739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255705.4 → XP_006255767.1  WAP four-disulfide core domain protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006255767.1

      UniProtKB/Swiss-Prot
      O70280
      UniProtKB/TrEMBL
      A6IZK1
      Conserved Domains (1) summary
      pfam00095
      Location:70 → 98
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70280.1 GenPept UniProtKB/Swiss-Prot:O70280

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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